Protein Information

General Information
MoonProt ID237
First appeared in release1.0
Name(s)Leucyl-tRNA synthetase Leucine--tRNA ligase, cytoplasmic LeuRS Gene Name: LARS
UniProt IDQ9P2J5 (SYLC_HUMAN), Reviewed
GO termsGO:0006412 translation GO:0006418 tRNA aminoacylation for protein translation GO:0006429 leucyl-tRNA aminoacylation GO:0006450 regulation of translational fidelity GO:0010467 gene expression GO:0000166 nucleotide binding GO:0002161 aminoacyl-tRNA editing activity GO:0004812 aminoacyl-tRNA ligase activity GO:0004823 leucine-tRNA ligase activity GO:0005515 protein binding GO:0005524 ATP binding GO:0016874 ligase activity GO:0005737 cytoplasm GO:0005829 cytosol
Organisms for which functions have been demonstratedHomo sapiens (human, a mammal)
Sequence length1176
FASTA sequence>sp|Q9P2J5|SYLC_HUMAN Leucine--tRNA ligase, cytoplasmic OS=Homo sapiens GN=LARS PE=1 SV=2 MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQTSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKACADKLKREIELYGCPPDFPDEEEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFITTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTIYSPKDGQPCMDHDRQTGEGVGPQEYTLLKLKVLEPYPSKLSGLKGKNIFLVAATLRPETMFGQTNCWVRPDMKYIGFETVNGDIFICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKEDKGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAVTICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVDGFKGQKVQDVKKTIQKKMIDAGDALIYMEPEKQVMSRSSDECVVALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFEATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGNLHGQAESPLGIRPQQMTKEVWDYVFFKEAPFPKTQIAKEKLDQLKQEFEFWYPVDLRVSGKDLVPNHLSYYLYNHVAMWPEQSDKWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSADGMRLALADAGDTVEDANFVEAMADAGILRLYTWVEWVKEMVANWDSLRSGPASTFNDRVFASELNAGIIKTDQNYEKMMFKEALKTGFFEFQAAKDKYRELAVEGMHRELVFRFIEVQTLLLAPFCPHLCEHIWTLLGKPDSIMNASWPVAGPVNEVLIHSSQYLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRKHFEANNGKLPDNKVIASELGSMPELKKYMKKVMPFVAMIKENLEKMGPRILDLQLEFDEKAVLMENIVYLTNSLELEHIEVKFASEAEDKIREDCCPGKPLNVFRIEPGVSVSLVNPQPSNGHFSTKIEIRQGDNCDSIIRRLMKMNRGIKDLSKVKLMRFDDPLLGPRRVPVLGKEYTEKTPISEHAVFNVDLMSKKIHLTENGIRVDIGDTIIYLVH
Structure Information
PDB ID2WFD
Quaternary structure
SCOP
CATH3.90.740.10
TM Helix Predictionno TM helices
DisProt AnnotationNot in DisProt
Predicted Disorder Regions
Connections to Disease
OMIM ID
Function 1
Function descriptionLeucyl-tRNA synthetase, enzyme attaches leucine to its cognate tRNA ATP + L-leucine + tRNA(Leu) => AMP + diphosphate + L-leucyl-tRNA(Leu) protein synthesis
References for function
E.C. number6.1.1.4
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionGTPase-activating protein (GAP) senses intracellular leucing concentration and binds to Rag GTPase Rag signals to mTORC1 promotes translocation of mTORC1 to the lysosomal membrane
References for functionHan JM, Jeong SJ, Park MC, Kim G, Kwon NH, Kim HK, Ha SH, Ryu SH, Kim S. Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell. 2012 Apr 13. PMID: 22424946
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments