| General Information |
| MoonProt ID | 241 |
| First appeared in release | 1.0 |
| Name(s) | Multisynthase complex auxiliary component p43
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
Gene Name: Aimp1 |
| UniProt ID | P31230 (AIMP1_MOUSE), Reviewed |
| GO terms | GO:0001525 angiogenesis
GO:0001937 negative regulation of endothelial cell proliferation
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006412 translation
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007267 cell-cell signaling
GO:0050900 leukocyte migration
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0005125 cytokine activity
GO:0042803 protein homodimerization activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0009986 cell surface
GO:0017101 aminoacyl-tRNA synthetase multienzyme complex
GO:0030133 transport vesicle
GO:0031410 cytoplasmic vesicle
|
| Organisms for which functions have been demonstrated | Mus musculus (Mouse, mammal) |
| Sequence length | 310 |
| FASTA sequence | >sp|P31230|AIMP1_MOUSE Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Mus musculus GN=Aimp1 PE=1 SV=2
MATNDAVLKRLEQKGAEADQIIEYLKQQVALLKEKAILQATMREEKKLRVENAKLKKEIEELKQELILAEIHNGVEQVRVRLSTPLQTNCTASESVVQSPSVATTASPATKEQIKAGEEKKVKEKTEKKGEKKEKQQSAAASTDSKPIDASRLDLRIGCIVTAKKHPDADSLYVEEVDVGEAAPRTVVSGLVNHVPLEQMQNRMVVLLCNLKPAKMRGVLSQAMVMCASSPEKVEILAPPNGSVPGDRITFDAFPGEPDKELNPKKKIWEQIQPDLHTNAECVATYKGAPFEVKGKGVCRAQTMANSGIK
|
| Structure Information |
| PDB ID | |
| Quaternary structure | |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-9, 101-144, 305-310 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | scaffold protein in the multisynthase complex
forms a multi-protein complex with glutamyl-, prolyl-, isoelucyl-, leucyl-, methionyl-, glutaminyl-, lysyl-, arginyl-, and aspartyl-tRNA synthetases, AIMP2/p38, and AIMP3/p18 |
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | cytokine
roles in angiogenesis - inducing endothelial cell migration
induces maturation of dendritic cells
induces monocyte cell adhesion
|
| References for function | Park SG, Choi EC, Kim S. Aminoacyl-tRNA synthetase-interacting multifunctional proteins (AIMPs): a triad for cellular homeostasis. IUBMB Life. 2010 Apr. PMID: 20306515 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | secreted |
| Comments | |