| General Information |
| MoonProt ID | 249 |
| First appeared in release | 1.0 |
| Name(s) | Protein argonaute 4
Protein overexpressor of cationic peroxidase II
Gene Name: AGO4 |
| UniProt ID | Q9ZVD5 (AGO4_ARATH), Reviewed |
| GO terms | GO:0000023 maltose metabolic process
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0000724 double-strand break repair via homologous recombination
GO:0000911 cytokinesis by cell plate formation
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006275 regulation of DNA replication
GO:0006306 DNA methylation
GO:0006342 chromatin silencing
GO:0006346 methylation-dependent chromatin silencing
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006417 regulation of translation
GO:0006952 defense response
GO:0007267 cell-cell signaling
GO:0008283 cell proliferation
GO:0009555 pollen development
GO:0009616 virus induced gene silencing
GO:0009816 defense response to bacterium, incompatible interaction
GO:0009855 determination of bilateral symmetry
GO:0009909 regulation of flower development
GO:0009965 leaf morphogenesis
GO:0010014 meristem initiation
GO:0010073 meristem maintenance
GO:0010267 production of ta-siRNAs involved in RNA interference
GO:0016032 viral process
GO:0016246 RNA interference
GO:0016444 somatic cell DNA recombination
GO:0016458 gene silencing
GO:0016568 chromatin modification
GO:0016569 covalent chromatin modification
GO:0016570 histone modification
GO:0016572 histone phosphorylation
GO:0019252 starch biosynthetic process
GO:0030422 production of siRNA involved in RNA interference
GO:0031047 gene silencing by RNA
GO:0031048 chromatin silencing by small RNA
GO:0034968 histone lysine methylation
GO:0035196 production of miRNAs involved in gene silencing by miRNA
GO:0043085 positive regulation of catalytic activity
GO:0048449 floral organ formation
GO:0051225 spindle assembly
GO:0051567 histone H3-K9 methylation
GO:0051726 regulation of cell cycle
GO:0010495 long-distance posttranscriptional gene silencing
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0035197 siRNA binding
GO:0005634 nucleus
GO:0005719 nuclear euchromatin
GO:0005730 nucleolus
GO:0015030 Cajal body
GO:0030529 ribonucleoprotein complex
GO:0005829 cytosol |
| Organisms for which functions have been demonstrated | Arabidopsis thaliana (Mouse-ear cress, a plant) |
| Sequence length | 924 |
| FASTA sequence | >sp|Q9ZVD5|AGO4_ARATH Protein argonaute 4 OS=Arabidopsis thaliana GN=AGO4 PE=1 SV=2
MDSTNGNGADLESANGANGSGVTEALPPPPPVIPPNVEPVRVKTELAEKKGPVRVPMARKGFGTRGQKIPLLTNHFKVDVANLQGHFFHYSVALFYDDGRPVEQKGVGRKILDKVHQTYHSDLDGKEFAYDGEKTLFTYGALPSNKMDFSVVLEEVSATRANGNGSPNGNESPSDGDRKRLRRPNRSKNFRVEISYAAKIPLQALANAMRGQESENSQEAIRVLDIILRQHAARQGCLLVRQSFFHNDPTNCEPVGGNILGCRGFHSSFRTTQGGMSLNMDVTTTMIIKPGPVVDFLIANQNARDPYSIDWSKAKRTLKNLRVKVSPSGQEFKITGLSDKPCREQTFELKKRNPNENGEFETTEVTVADYFRDTRHIDLQYSADLPCINVGKPKRPTYIPLELCALVPLQRYTKALTTFQRSALVEKSRQKPQERMTVLSKALKVSNYDAEPLLRSCGISISSNFTQVEGRVLPAPKLKMGCGSETFPRNGRWNFNNKEFVEPTKIQRWVVVNFSARCNVRQVVDDLIKIGGSKGIEIASPFQVFEEGNQFRRAPPMIRVENMFKDIQSKLPGVPQFILCVLPDKKNSDLYGPWKKKNLTEFGIVTQCMAPTRQPNDQYLTNLLLKINAKLGGLNSMLSVERTPAFTVISKVPTIILGMDVSHGSPGQSDVPSIAAVVSSREWPLISKYRASVRTQPSKAEMIESLVKKNGTEDDGIIKELLVDFYTSSNKRKPEHIIIFRDGVSESQFNQVLNIELDQIIEACKLLDANWNPKFLLLVAQKNHHTKFFQPTSPENVPPGTIIDNKICHPKNNDFYLCAHAGMIGTTRPTHYHVLYDEIGFSADELQELVHSLSYVYQRSTSAISVVAPICYAHLAAAQLGTFMKFEDQSETSSSHGGITAPGPISVAQLPRLKDNVANSMFFC |
| Structure Information |
| PDB ID | |
| Quaternary structure | |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-52, 160-181, 240-251, 354-356, 703-711, 791-796, 884-907 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Component of the RISC complex
RNA-directed DNA methylation, involves small interfering RNA (siRNA)
RNA-directed gene silencing
|
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | |
| Function 2 |
| Function description | cleaves RNA transcripts, enzyme
generates small interfering RNAs (siRNAs)
|
| References for function | Qi Y, He X, Wang XJ, Kohany O, Jurka J, Hannon GJ. Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation. Nature. 2006 Oct 26. PMID: 16998468 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |