| General Information |
| MoonProt ID | 25 |
| First appeared in release | 1.0 |
| Name(s) | Enolase
2-phospho-D-glycerate hydro-lyase
2-phosphoglycerate dehydratase
Gene Name: eno |
| UniProt ID | Q8GE63 (ENO_AERHY), Reviewed |
| GO terms | GO:0006096 glycolysis
GO:0000287 magnesium ion binding
GO:0004634 phosphopyruvate hydratase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0000015 phosphopyruvate hydratase complex
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0009986 cell surface |
| Organisms for which functions have been demonstrated | Aeromonas hydrophila (soft-tissue infections, with cellulitis being most frequent) |
| Sequence length | 433 |
| FASTA sequence | >gi|25989631|gb|AAN28926.1| enolase [Aeromonas hydrophila]
MSKIVKVIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFLGKGVLKALEAVNGPIAQALLGKDAKDQATVDQIMIDLDGTENKSKFGANAILAVSLANAKAAAAAKGMPLYAHIAELNGTPGVYSMPLPMMNIINGGEHADNNVDIQEFMIQPVGAKTLKEAVRMGAEVFHNLAKVLKSKGYNTAVGDEGGFAPNLKSNAEALEVIAEAVAAAGYKLGTDVTLAMDCAASEFYDAEKKEYNLKGEGRVFTSNGFSDFLEELTAKFPIVSIEDGLDESDWEGFAYQTQKLGKKIQIVGDDLFVTNTKILKRGIDNGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGAKAPFRGLKEVKNQA |
| Structure Information |
| PDB ID | 6BFY_A |
| Quaternary structure | |
| SCOP | Enolase N-terminal domain-like, TIM beta/alpha-barrel |
| CATH | 3.30.390.10, 3.20.20.120 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-3,39-43,427-433 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enolase, enzyme
2-phospho-D-glycerate => phosphoenolpyruvate + H2O
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.
Carbohydrate degradation, glycolysis
|
| References for function | |
| E.C. number | 4.2.1.11 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | plasminogen binding
(binds human plasminogen) |
| References for function | Sha J, Erova TE, Alyea RA, Wang S, Olano JP, Pancholi V, Chopra AK. Surface-expressed enolase contributes to the pathogenesis of clinical isolate SSU of Aeromonas hydrophila. J Bacteriol. 2009 May;191(9):3095-107. doi: 10.1128/JB.00005-09. Epub 2009 Mar 6.
PMID: 19270100 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |