| General Information |
| MoonProt ID | 252 |
| First appeared in release | 1.0 |
| Name(s) | Pyruvate kinase PKM
Pyruvate kinase muscle isozyme
Gene Name: Pkm |
| UniProt ID | P11980 (KPYM_RAT), Reviewed |
| GO terms | GO:0001666 response to hypoxia
GO:0001889 liver development
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
GO:0006754 ATP biosynthetic process
GO:0007584 response to nutrient
GO:0008152 metabolic process
GO:0009629 response to gravity
GO:0010033 response to organic substance
GO:0014870 response to muscle inactivity
GO:0016310 phosphorylation
GO:0031100 organ regeneration
GO:0032868 response to insulin
GO:0042866 pyruvate biosynthetic process
GO:0043403 skeletal muscle tissue regeneration
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0030955 potassium ion binding
GO:0043531 ADP binding
GO:0046872 metal ion binding
GO:0005634 nucleus
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Rattus norvegicus (rat, a mammal) |
| Sequence length | 531 |
| FASTA sequence | >sp|P11980|KPYM_RAT Pyruvate kinase PKM OS=Rattus norvegicus GN=Pkm PE=1 SV=3
MPKPDSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLFEELARASSQSTDPLEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLDAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
|
| Structure Information |
| PDB ID | |
| Quaternary structure | |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-14, 399-406 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Pyruvate kinase, enzyme
ATP + pyruvate => ADP + phosphoenolpyruvate
Carbohydrate degradation, glycolysis
enzyme as tetramer |
| References for function | Parkison C, Ashizawa K, McPhie P, Lin KH, Cheng SY. The monomer of pyruvate kinase, subtype M1, is both a kinase and a cytosolic thyroid hormone binding protein. Biochem Biophys Res Commun. 1991 Aug 30. PMID: 1883388 |
| E.C. number | 2.7.1.40 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | thyroid hormone binding activity
monomer binds 3,3',5-triiodo-L-thyronine (T3)
|
| References for function | Parkison C, Ashizawa K, McPhie P, Lin KH, Cheng SY. The monomer of pyruvate kinase, subtype M1, is both a kinase and a cytosolic thyroid hormone binding protein. Biochem Biophys Res Commun. 1991 Aug 30;179(1):668-74.
PMID: 1883388 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |