| General Information |
| MoonProt ID | 253 |
| First appeared in release | 1.0 |
| Name(s) | Sulfite reductase
Sulfite reductase [ferredoxin], chloroplastic
PsSiR
Gene Name:SIR |
| UniProt ID | Q75NZ0 (SIR_PEA), Reviewed |
| GO terms | GO:0006275 regulation of DNA replication
GO:0006323 DNA packaging
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0019424 sulfide oxidation, using siroheme sulfite reductase
GO:0045892 negative regulation of transcription, DNA-templated
GO:0055114 oxidation-reduction process
GO:0003677 DNA binding
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0050311 sulfite reductase (ferredoxin) activity
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0009507 chloroplast
GO:0009532 plastid stroma
GO:0009536 plastid
GO:0009570 chloroplast stroma
GO:0042644 chloroplast nucleoid |
| Organisms for which functions have been demonstrated | Pisum sativum (garden pea) |
| Sequence length | 685 |
| FASTA sequence | >sp|Q75NZ0|SIR_PEA Sulfite reductase [ferredoxin], chloroplastic OS=Pisum sativum GN=SIR PE=1 SV=2
MTTSFAAAALRDPKLQIPNYHGLRSSSAASSLSRNALSVPSSTRSSSLIRAVSTPAKSETATEKKRSKVEIFKEQSNFIRYPLNEDMLTDAPNLSEAATQLIKFHGSYQQYNRDERGSRTYSFMIRTKNPCGKVSNQLYLTMDDLADQFGIGTLRLTTRQTFQLHGVVKKDLKTVMGSIIRNMGSSLGACGDLNRNVLAPAAPIVSKDYLFAQETSENIAALLTPQSGFYYDVWVDGERFMSAEPPEVIQARNDNSHGTNFTDSPEPIYGTQFLPRKFKIAVTVPTDNSVDILTNDIGVVVVTGDGGEPQGFNLYVGGGMGRTHRMETTFPRLAEPLGYVPKEDILYAVKAIVVTQRENGRRDDRRYSRMKYLIDSWGIDKFRNVVEEYYGKKFEPFRSLPEWEFKSYLGWHQQGDGGLFCGLHVDNGRIAGKMKTALREVIEKYHLNVRLTPNQNLILTDIRAAWKRPITTILSQAGLLLPRYVDPLNITAMACPAFPLCPLAITEAERGIPSILKRIRDMFEKVGLKYNESVVVRITGCPNGCARPYMAELGLVGDGPNSYQIWLGGSSNQTSIARSFMDKVKPQDLEKVLEPLFYHWKQKRQSKESFGDFTVRLGFEKLKEFIEKWEGPAVPPTRHNLKLFTDKDTYEAMDGLAKLQNKNAHQLAMEVVRNYIASNLNGKGE
|
| Structure Information |
| PDB ID | |
| Quaternary structure | |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-12, 21-66, 75, 252-259, 397-401, 658-660, 675-685 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Sulfite reductase, enzyme
Hydrogen sulfide + 6 oxidized ferredoxin + 3 H2O <=> sulfite + 6 reduced ferredoxin + 6 H+
|
| References for function | |
| E.C. number | 1.8.7.1 |
| Location of functional site(s) | |
| Cellular location of function | plastid, chloroplast stroma |
| Comments | |
| Function 2 |
| Function description | compact DNA in nucleoids of plastids
method to regulate transcription
|
| References for function | Sekine K, Hase T, Sato N. Reversible DNA compaction by sulfite reductase regulates transcriptional activity of chloroplast nucleoids. J Biol Chem. 2002 Jul 5;277(27):24399-404.
PMID: 11997391 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | chloroplast nucleoids |
| Comments | |