| General Information |
| MoonProt ID | 26 |
| First appeared in release | 1.0 |
| Name(s) | Enolase
2-phospho-D-glycerate hydro-lyase
2-phosphoglycerate dehydratase
Gene Name: eno
|
| UniProt ID | B7GTK2 (ENO_BIFLS), Reviewed |
| GO terms | GO:0006096 glycolysis
GO:0000287 magnesium ion binding
GO:0004634 phosphopyruvate hydratase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0000015 phosphopyruvate hydratase complex
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0009986 cell surface |
| Organisms for which functions have been demonstrated | Bifidobacterium (B. longum, B. bifidum, B. breve and B. lactis) (Gram positive bacterium) |
| Sequence length | 432 |
| FASTA sequence | >gi|384199907|ref|YP_005585650.1| enolase [Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222]
MAVIESVYARQILDSRGNPTVEVYLETEDGAQGKGLVPSGASTGEAEAWERRDGDKSVYGGKGVLNAVKAVNEVIAPKVIGMDAADQRALDDLMIELDGTPNKGKLGANAILGVSLAALYASAESAGLPLYRYIGGTNGHILPVPNMNIMNGGAHADFATDIQEYMISPYGFDTYSEALRAGVEVYHTLKNVLKKEGLNTGLGDEGGFAPKMKSNEDSLKYIMDAISAAGYEPGKQIGICLDVASSEFYNKETGKYRFDGEERDSAYMLDYYENLINEYPIVSIEDPFNEEGWEDWAAITARLGDRLQFVGDDLLVTNPARLQKAIDLGAANSLLVKLNQIGSVTETLDAIELATANGYTSMVSHRSGETPDTTISDLAVAKNTRQIKTGAPARGERVAKYNRLLEIEEELGSTAQYAGYTAFKACKKYLAK |
| Structure Information |
| PDB ID | Closest homologue is 4YWS (61.56%) |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-3,427-432 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enolase, enzyme
2-phospho-D-glycerate => phosphoenolpyruvate + H2O
reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate
Carbohydrate degradation, glycolysis |
| References for function | Candela M, Biagi E, Centanni M, Turroni S, Vici M, Musiani F, Vitali B, Bergmann S, Hammerschmidt S, Brigidi P. Bifidobacterial enolase, a cell surface receptor for human plasminogen involved in the interaction with the host. Microbiology. 2009 Oct;155(Pt 10):3294-303.doi: 10.1099/mic.0.028795-0. Epub 2009 Jul 2.
PMID: 19574304 |
| E.C. number | EC=4.2.1.11
|
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | plasminogen binding
(binds human plasminogen) |
| References for function | Candela M, Biagi E, Centanni M, Turroni S, Vici M, Musiani F, Vitali B, Bergmann S, Hammerschmidt S, Brigidi P. Bifidobacterial enolase, a cell surface receptor for human plasminogen involved in the interaction with the host. Microbiology. 2009 Oct;155(Pt 10): 3294-303.doi: 10.1099/mic.0.028795-0. Epub 2009 Jul 2.
PMID: 19574304 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface, cell wall |
| Comments | |