| General Information |
| MoonProt ID | 261 |
| First appeared in release | 1.0 |
| Name(s) | Autolysin AtlA
Gene Name:atlA |
| UniProt ID | U3SW74 (U3SW74_STRMG), Unreviewed |
| GO terms | GO:0005975 carbohydrate metabolic process
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0003796 lysozyme activity |
| Organisms for which functions have been demonstrated | Streptococcus mutans |
| Sequence length | 979 |
| FASTA sequence | >tr|U3SW74|U3SW74_STRMG Autolysin AtlA OS=Streptococcus mutans LJ23 GN=atlA PE=4 SV=1
MKSKTYLMIPLALTLFMAANKISADEQNQSLSASEVISSDATSVSELPATTAQISQEVRNNGQDSTIQLQQTQEQSDPITSTSETTVSSMKVATNGSPAKANETETVPSQASTASSVQTPDQISTVPSVKAETTSTADQLQSTSSAPLDQQTDAKRLSNKMTPASSVQARSSLTQDKQVQAQEVTSAVVEEKGIKLQYNGQIARNTKIQFAVWSARNDQDDLQWYTANNMGAAYAEFKNHREYGTYYVHTYANQNGKMIGLNATTLTIAQPQVQTNIQRKSATNFELTVSNVPNTISSIMVPVWSDQNGQDDIKWYNARKADDGSYKVLIDTKNHKNDLGHYEAHIYGYSTVTQSQIGLAVSSGFDRNDTRPNARISVANYDQNKTTFDVVVEGSSDTKTVSAVNIAVWSEDKGQDDLKWYSPKIVNNKATVTINIANHSNTSDKYNVHVYTDYTDGTHSGTILGAYQINKPLEKNTVSADLTSDGIALKLDSNTVTDYTKVRFAVWSDQNGQDDLKWYSANSDGAATAAYSNHSGYGLYHIHTYIIKDGKMVGLNGRTITINQPSAKVDIAKESDALYKVTVSNLPAYISSVVIPVWTDKNNQDDIQWIPATKQGDGTYAAQIQLADHNGETGHYNVHVYGQSKFDNKTVGLAATDGFNVAETRNAVIAASNYNASAGTIDMIVKQEAGGKAIKEVRIAAWSEADQSNLHWYVSSTIIDGKVTVTINEKNHQYIKGNYNIHVYVDYTDGTSSGTNIGNYSLNADKPAVDLPSYFIDISSHNGIISVAEFNSLKQQGIQGVVVKLTEGTSYINPYASSQIANARAAGIKVSAYHYAHYTSAAEAQEEARYFANAARSFGLEASTVTVNDMEESSMVNNINNNVQAWQDEMRRQGYSNLIHYTMASWLDIRGGQVDTARFGINNFWVAHYAKGYTYMTQEEAKSLNYYANAAAWQYTSVSSKLSHALDENIDYTGRFTQQ
|
| Structure Information |
| PDB ID | None, closest homologue different species, 34.62% Chain A, Endolysin [Clostridium phage phiCTP1] 5A6S |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-10, 24-178, 358-370, 460-468, 477-479, 651-664, 759-764, 766, 768, 974-979 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | autolysin, enzyme
cleaves cell wall peptidoglycan |
| References for function | |
| E.C. number | 3.5.1.28 |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |
| Function 2 |
| Function description | binds fibronectin |
| References for function | Jung CJ, Zheng QH, Shieh YH, Lin CS, Chia JS. Streptococcus mutans autolysin AtlA is a fibronectin-binding protein and contributes to bacterial survival in the bloodstream and virulence for infective endocarditis. Mol Microbiol. 2009 Nov;74(4):888-902. doi: 10.1111/j.1365-2958.2009.06903.x.
PMID: 19818020 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |