| General Information |
| MoonProt ID | 273 |
| First appeared in release | 1.0 |
| Name(s) | Fructose-bisphosphate aldolase |
| UniProt ID | P49577 |
| GO terms | GO:0006096 glycolytic process
GO:0003824 catalytic activity
GO:0004332 fructose-bisphosphate aldolase activity
GO:0016829 lyase activity |
| Organisms for which functions have been demonstrated | Plasmodium berghei |
| Sequence length | 358 aa |
| FASTA sequence | >sp|P49577|ALF2_PLABA Fructose-bisphosphate aldolase 2 OS=Plasmodium berghei (strain Anka) GN=ALDO2 PE=3 SV=1
MKLPKEDAQELAETAKKLVAAGKGILAADESTQTIKKRFDNIKIENTVQNRASYRDLLFGTKGLGKFISGAILFEETLFQKNEAGVPLVNLLHDEGIIPGIKVDKGLVSIPCTDDEKSTQGLDGLAERCKEYYKAGARFAKWRAVLVIDPAKGKPTDLSIQEVSWGLARYASICQQNKLVPIVEPEILADGAHTIEVCATVTQKVLASVFKALHDNGVLLEGASLKPNMVTAGYDCTEKTKTDDIGFFTVRTLRRTVPPALPGVAFLSGGQSEEDASINLNSINVLGPHPWALTFSYGRALQASVLNTWQGKKENVAKARRVLLQRAEANSLATYGKYKGGAGGSTAGASLYEKKYVY
|
| Structure Information |
| PDB ID | 2EPH,
2PC4,
1A5C |
| Quaternary structure | |
| SCOP | NA |
| CATH | 3.20.20.70 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-9, 339-358 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Fructose-bisphosphate aldolase, enzyme
D-fructose 1,6-bisphosphate => dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate
Carbohydrate degradation, glycolysis |
| References for function | |
| E.C. number | 4.1.2.13 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | attaches actin filaments to TRAP proteins (transmembrane adhesive proteins of the thrombospondin-related anonymous protein) and transduces the motor force across the surface of the plasmodium
|
| References for function | Bosch J, Buscaglia CA, Krumm B, Ingason BP, Lucas R, Roach C, Cardozo T, Nussenzweig V, Hol WG. Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite. Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7015-20.
PMID: 17426153 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm, near plasma membrane |
| Comments | |