| General Information |
| MoonProt ID | 282 |
| First appeared in release | 1.0 |
| Name(s) | P0 ribosomal protein
60S acidic ribosomal protein P0
Apurinic-apyrimidinic endonuclease
DNA-(apurinic or apyrimidinic site) lyase
Gene Name:RpLP0 |
| UniProt ID | P19889 (RLA0_DROME), Reviewed |
| GO terms | GO:0000737 DNA catabolic process, endonucleolytic
GO:0006281 DNA repair
GO:0006414 translational elongation
GO:0006974 cellular response to DNA damage stimulus
GO:0042254 ribosome biogenesis
GO:0003735 structural constituent of ribosome
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity
GO:0016829 lyase activity
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0030529 ribonucleoprotein complex |
| Organisms for which functions have been demonstrated | Drosophila melanogaster (fruit fly, an insect) |
| Sequence length | 317 |
| FASTA sequence | >sp|P19889|RLA0_DROME 60S acidic ribosomal protein P0 OS=Drosophila melanogaster GN=RpLP0 PE=1 SV=1
MVRENKAAWKAQYFIKVVELFDEFPKCFIVGADNVGSKQMQNIRTSLRGLAVVLMGKNTMMRKAIRGHLENNPQLEKLLPHIKGNVGFVFTKGDLAEVRDKLLESKVRAPARPGAIAPLHVIIPAQNTGLGPEKTSFFQALSIPTKISKGTIEIINDVPILKPGDKVGASEATLLNMLNISPFSYGLIVNQVYDSGSIFSPEILDIKPEDLRAKFQQGVANLAAVCLSVGYPTIASAPHSIANGFKNLLAIAATTEVEFKEATTIKEYIKDPSKFAAAASASAAPAAGGATEKKEEAKKPESESEEEDDDMGFGLFD
|
| Structure Information |
| PDB ID | None, closest homologue is 79.82% Chain q, 60s Acidic Ribosomal Protein P0 [Drosophila melanogaster] 3J39 |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-7, 127-132, 278-317 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | P0 ribosomal protein
part of the 60S subunit |
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm, part of the ribosome |
| Comments | |
| Function 2 |
| Function description | Apurinic-apyrimidinic endonuclease, enzyme
functions in DNA repair
act on AP DNA, cleaves 5' of a baseless site
|
| References for function | Yacoub A, Kelley MR, Deutsch WA. Drosophila ribosomal protein PO contains apurinic/apyrimidinic endonuclease activity. Nucleic Acids Res. 1996 Nov 1;24(21):4298-303.
PMID: 8932386 |
| E.C. number | 4.2.99.18 |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | |