| General Information |
| MoonProt ID | 289 |
| First appeared in release | 4.0 |
| Name(s) | Aqs1 |
| UniProt ID | NA |
| GO terms | NA |
| Organisms for which functions have been demonstrated | DMS3 phage of Pseudomonas aeruginosa |
| Sequence length | NA |
| FASTA sequence | NA |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | NA |
| DisProt Annotation | NA |
| Predicted Disorder Regions | NA |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | binds hostLasRprotein, inhibits quorum sensing through adirect interaction with the DNA-binding domain of LasR, themaster regulator of quorum sensing |
| References for function | Shah M, Taylor VL, Bona D, Tsao Y, Stanley SY, Pimentel-Elardo SM, McCallum M, Bondy-Denomy J, Howell PL, Nodwell JR, Davidson AR, Moraes TF, Maxwell KL. A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa. Mol Cell. 2021 Feb 4;81(3):571-583.e6. doi: 10.1016/j.molcel.2020.12.011. Epub 2021 Jan 6. PMID: 33412111. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |
| Function 2 |
| Function description | binds host PilB protein, blocking type IV pilus assembly, which is the cell surface receptor for phage DMS3 and many other P. aeruginosa phages |
| References for function | Shah M, Taylor VL, Bona D, Tsao Y, Stanley SY, Pimentel-Elardo SM, McCallum M, Bondy-Denomy J, Howell PL, Nodwell JR, Davidson AR, Moraes TF, Maxwell KL. A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa. Mol Cell. 2021 Feb 4;81(3):571-583.e6. doi: 10.1016/j.molcel.2020.12.011. Epub 2021 Jan 6. PMID: 33412111. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |