| General Information |
| MoonProt ID | 303 |
| First appeared in release | 2.0 |
| Name(s) | aldolase, fructose-1,6-bisphosphate aldolase, fructose-bisphosphate aldolase, Gene: LDBPK_361320 |
| UniProt ID | E9BTJ1 (E9BTJ1_LEIDB) |
| GO terms | GO:0006096 glycolytic process
GO:0003824 catalytic activity
GO:0004332 fructose-bisphosphate aldolase activity
GO:0016829 lyase activity |
| Organisms for which functions have been demonstrated | |
| Sequence length | 371 amino acids |
| FASTA sequence | >tr|E9BTJ1|E9BTJ1_LEIDB Fructose-bisphosphate aldolase OS=Leishmania donovani (strain BPK282A1) GN=LDBPK_361320 PE=3 SV=1
MSRVTIFQSQLPACNRLKTPYESELIATVKKLTTPGKGLLAADESIGSCTKRFEPIGLSNTEEHRRQYRALMLEAEGFEQYISGVILHEETVGQKASNGQTFPEYLTARGVVPGIKTDMGLCPLLEGAEGEQMTEGLDGYVKRASAYYKKGCRFCKWRNVYKIQNGTVSESAVRFNAETLARYAILSQISGLVPIVEPEVMIDGKHDIDTCQRVSEHVWREVVAALQRHGVIWEGCLLKPNMVVPGAESGQTAAPAQVAHYTVMTLARTMPAMLPGVMFLSGGLSEVQASEYLNAINNSPLPRPYFLSFSYARALQSSALKAWGGKDSGVAAGRRAFLHRARMNSMAQLGKYKRADDDASSSSLYVKGNTY |
| Structure Information |
| PDB ID | None, but structures available from L. mexicana aldolase |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-13, 353-363, 369-371 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | aldolase, cleavage of fructose-1,6-bisphosphate to
glyceraldehyde 3-phosphate and dihydroxyacetone phosphate, in glycolysis |
| References for function | |
| E.C. number | 4.1.2.13 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | Activation of mouse (host) macrophage protein tyrosine phosphatase-1 (SHP-1), causes macrophage disfunction |
| References for function | |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | secreted |
| Comments | |