| General Information |
| MoonProt ID | 304 |
| First appeared in release | 2.0 |
| Name(s) | aldolase, fructose-1,6-bisphosphate aldolase, fructose-bisphosphate aldolase, muscle-type aldolase, aldolase 1, Gene: Aldoa |
| UniProt ID | P05064 (ALDOA_MOUSE) |
| GO terms | GO:0006000 fructose metabolic process
GO:0006096 glycolytic process
GO:0006754 ATP biosynthetic process
GO:0006941 striated muscle contraction
GO:0008360 regulation of cell shape
GO:0030388 fructose 1,6-bisphosphate metabolic process
GO:0046716 muscle cell cellular homeostasis
GO:0051289 protein homotetramerization
GO:0061615 glycolytic process through fructose-6-phosphate
GO:0002020 protease binding
GO:0003824 catalytic activity
GO:0004332 fructose-bisphosphate aldolase activity
GO:0008092 cytoskeletal protein binding
GO:0016829 lyase activity
GO:0044822 poly(A) RNA binding
GO:0070061 fructose binding |
| Organisms for which functions have been demonstrated | Mus musculus (Mouse, mammal) |
| Sequence length | 364 amino acids |
| FASTA sequence | >sp|P05064|ALDOA_MOUSE Fructose-bisphosphate aldolase A OS=Mus musculus GN=Aldoa PE=1 SV=2
MPHPYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHVYLEGTLLKPNMVTPGHACTQKFSNEEIAMATVTALRRTVPPAVTGVTFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYIKRALANSLACQGKYTPSGQSGAAASESLFISNHAY |
| Structure Information |
| PDB ID | None, closest homologue from homo sapiens, 97.80% Chain A, ALDOLASE A [Homo sapiens] 1ALD |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-11, 344-355, 362-364 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | aldolase, in glycolysis and gluconeogenesis, reversible cleavage of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. |
| References for function | |
| E.C. number | |
| Location of functional site(s) | cytoplasm |
| Cellular location of function | |
| Comments | |
| Function 2 |
| Function description | bind to and regulate insulin-dependent glucose transporter GLUT4 |
| References for function | Kao AW, Noda Y, Johnson JH, Pessin JE, Saltiel AR. Aldolase mediates the association of F-actin with the insulin-responsive glucose transporter GLUT4. J Biol Chem. 1999 Jun 18;274(25):17742-7. PMID: 10364216. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | GLUT4 is in adipoase tissue, skeletal muscle, cardiac muscle |