| General Information |
| MoonProt ID | 307 |
| First appeared in release | 2.0 |
| Name(s) | aldolase A, ALDOA, Fructose-bisphosphate aldolase A, lung cancer antigen NY-LU-1, Muscle-type aldolase
Gene: ALDOA |
| UniProt ID | P04075 (ALDOA_HUMAN) |
| GO terms | GO:0002576 platelet degranulation
GO:0006000 fructose metabolic process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0006754 ATP biosynthetic process
GO:0006941 striated muscle contraction
GO:0007015 actin filament organization
GO:0008360 regulation of cell shape
GO:0030388 fructose 1,6-bisphosphate metabolic process
GO:0046716 muscle cell cellular homeostasis
GO:0051289 protein homotetramerization
GO:0061621 canonical glycolysis
GO:0003779 actin binding
GO:0003824 catalytic activity
GO:0004332 fructose-bisphosphate aldolase activity
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0015631 tubulin binding |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 364 amino acids |
| FASTA sequence | >sp|P04075|ALDOA_HUMAN Fructose-bisphosphate aldolase A OS=Homo sapiens GN=ALDOA PE=1 SV=2
MPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKFSHEEIAMATVTALRRTVPPAVTGITFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSGQAGAAASESLFVSNHAY |
| Structure Information |
| PDB ID | 4ALD |
| Quaternary structure | |
| SCOP | TIM beta/alpha-barrel |
| CATH | 3.20.20.70 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-10, 344-355, 362-364 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | aldolase, D-fructose 1,6-bisphosphate-> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate, in glycolysis |
| References for function | |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | interactions with zona pellucida proteins of egg |
| References for function | Petit FM, Serres C, Bourgeon F, Pineau C, Auer J. (2013) Identification of sperm head proteins involved in zona pellucida binding. Hum. Reprod. 28, 852–865. PMID: 23355646. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | head of sperm, sperm membrane |
| Comments | |