| General Information |
| MoonProt ID | 309 |
| First appeared in release | 2.0 |
| Name(s) | ask1, Gene: GSTUMT00005863001 |
| UniProt ID | D5GCF2 (D5GCF2_TUBMM) |
| GO terms | GO:0008608 attachment of spindle microtubules to kinetochore
GO:0000778 condensed nuclear chromosome kinetochore
GO:0005634 nucleus
GO:0005829 cytosol
GO:0042729 DASH complex
GO:0044732 mitotic spindle pole body
GO:0072686 mitotic spindle |
| Organisms for which functions have been demonstrated | Tuber melanosporum |
| Sequence length | 410 amino acids |
| FASTA sequence | >tr|D5GCF2|D5GCF2_TUBMM Uncharacterized protein OS=Tuber melanosporum (strain Mel28) GN=GSTUM_00005863001 PE=4 SV=1
MSRPPLSLTAELEKLEQSITLTLQEIDHNFSKAHRIVTTSIIPIVERYAKESEAVWEGSKFWKQFFEASANVALSNYQEEEETYEETGVATNAETYITASSPGNYGEQSTRITQEDDPRHRETQWENIESPFDALRKDDDADMTFEPTLLPATPQTSRRTRPAKGSFETPKSSPFYPSAAGAIGKKTPGGANEDQLLHRVLDKNWRLQATPLGKPPPSRYRTIGAATATTPKAQILPPPGSESPMSSPPKPHFYSADIFSSPIPGFGGFDGGKKPKPSTTSNTTVLAGDPKTPISRRYGTAKVTTTHHHELSQQGDEGRFAYGYDDDDDSDDLDLPPGLSPPVTIQFSLPPSKLLATPAREASRRIVHDILQTAGAADESGATGGSSPPVVRDVGPLDDTF |
| Structure Information |
| PDB ID | None, closest homologue to Chain A, Ask1 [Chaetomium thermophilum] 75.68% 6CFZ |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-10, 30-65, 199-218, 243-251 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | part of DASH complex, which binds to microtubules and kinetochores and regulates their association |
| References for function | |
| E.C. number | |
| Location of functional site(s) | cytoplasm |
| Cellular location of function | |
| Comments | |
| Function 2 |
| Function description | transcriptional regulator |
| References for function | Montanini B, Levati E, Bolchi A, Kohler A, Morin E, Tisserant E, Martin F, Ottonello S. Genome-wide search and functional identification of transcription factors in the mycorrhizal fungus Tuber melanosporum.
New Phytol. 2011 Feb;189(3):736-50. doi: 10.1111/j.1469-8137.2010.03525.x. PMID: 21058951. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | |