General Information |
MoonProt ID | 311 |
First appeared in release | 2.0 |
Name(s) | beta-arrestin-2, Gene: ARRB2 |
UniProt ID | P32121 (ARRB2_HUMAN) |
GO terms | GO:0001932 regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0002031 G-protein coupled receptor internalization
GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin
GO:0002092 positive regulation of receptor internalization
GO:0006366 transcription from RNA polymerase II promoter
GO:0006810 transport
GO:0006897 endocytosis
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007212 dopamine receptor signaling pathway
GO:0007420 brain development
GO:0007628 adult walking behavior
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0009968 negative regulation of signal transduction
GO:0015031 protein transport |
Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
Sequence length | 409 amino acids |
FASTA sequence | >sp|P32121|ARRB2_HUMAN Beta-arrestin-2 OS=Homo sapiens GN=ARRB2 PE=1 SV=2
MGEKPGTRVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLVDPDYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLFIATYQAFPPVPNPPRPPTRLQDRLLRKLGQHAHPFFFTIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSLEEKSHKRNSVRLVIRKVQFAPEKPGPQPSAETTRHFLMSDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADICLFSTAQYKCPVAQLEQDDQVSPSSTFCKVYTITPLLSDNREKRGLALDGKLKHEDTNLASSTIVKEGANKEVLGILVSYRVKVKLVVSRGGDVSVELPFVLMHPKPHDHIPLPRPQSAAPETDVPVDTNLIEFDTNYATDDDIVFEDFARLRLKGMKDDDYDDQLC |
Structure Information |
PDB ID | None, 76.74% similarity with Chain A, Beta-arrestin-1 [Homo sapiens], but 97.71% similarity with Chain A, Beta-arrestin-2 [Bos taurus] 5TV1 |
Quaternary structure | |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1-7, 95, 178-183, 350-370, 399-409 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | uncouple activated seven-transmembrane receptors from heterotrimeric G proteins, mediate the endocytosis of most G-protein-coupled receptors (GPCRs) |
References for function | |
E.C. number | |
Location of functional site(s) | cytoplasm |
Cellular location of function | |
Comments | |
Function 2 |
Function description | regulates transcription
|
References for function | Neuhaus EM, Mashukova A, Barbour J, Wolters D, Hatt H. Novel function of beta-arrestin2 in the nucleus of mature spermatozoa. J Cell Sci. 2006 Aug 1;119(Pt 15):3047-56. PMID: 16820410. |
E.C. number | |
Location of functional site(s) | nucleus |
Cellular location of function | |
Comments | |