| General Information |
| MoonProt ID | 312 |
| First appeared in release | 2.0 |
| Name(s) | C5a peptidase, Streptococcal C5a peptidase, Gene: ScpB |
| UniProt ID | Q8E4T9 (Q8E4T9_STRA3) |
| GO terms | GO:0006508 proteolysis
GO:0004252 serine-type endopeptidase activity
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity
GO:0005618 cell wall
GO:0016020 membrane
GO:0016021 integral component of membrane |
| Organisms for which functions have been demonstrated | Streptococcus agalactiae, group B streptococci (GBS) (Gram positive bacterium) |
| Sequence length | 1150 amino acids |
| FASTA sequence | >tr|Q8E4T9|Q8E4T9_STRA3 Streptococcal C5a peptidase OS=Streptococcus agalactiae serotype III (strain NEM316) GN=scpB PE=3 SV=1
MRKKQKLPFDKLAIALMSTSILLNAQSDIKANTVTEDTPATEQTVETPQPTAVSEEAPSSKETKTPQTPSDAGETVADDANDLAPQAPAKTADTPATSKATIRDLNDPSQVKTLQEKAGKGAGTVVAVIDAGFDKNHEAWRLTDKAKARYQSKEDLEKAKKEHGITYGEWVNDKVAYYHDYSKDGKTAVDQEHGTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLADYARNYAQAIRDAINLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSAGNDSSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETATVKTADQQDKEMPVLSTNRFEPNKAYDYAYANRGTKEDDFKDVKGKIALIERGDIDFKDKIAKAKKAGAVGVLIYDNQDKGFPIELPNVDQMPAAFISRKDGLLLKDNPQKTITFNATPKVLPTASGTKLSRFSSWGLTADGNIKPDIAAPGQDILSSVANNKYAKLSGTSMSAPLVAGIMGLLQKQYETQYPDMTPSERLDLAKKVLMSSATALYDEDEKAYFSPRQQGAGAVDAKKASAATMYVTDKDNTSSKVHLNNVSDKFEVTVTVHNKSDKPQELYYQATVQTDKVDGKHFALAPKALYETSWQKITIPANSS |
| Structure Information |
| PDB ID | None, but some structures from very close homologues are available |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | protease, peptidase, endopeptidase, cleaves and inactivates C5a (a component of the human complement system), helps GBS evade phagocytosis |
| References for function | |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |
| Function 2 |
| Function description | fibronectin binding, adhesin |
| References for function | Beckmann C, Waggoner JD, Harris TO, Tamura GS, Rubens CE: Identification of novel adhesins from Group B streptococci by use of phage display reveals that C5a peptidase mediates fibronectin binding. Infect Immun 2002, 70(6):2869-2876. PMID: 12010974. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |