General Information |
MoonProt ID | 319 |
First appeared in release | 2.0 |
Name(s) | EF-1alpha, elongation factor 1alpha,EF-1-alpha-1, Elongation factor Tu, EF-Tu, Eukaryotic elongation factor 1 A-1, eEF1A-1, Leukocyte receptor cluster member 7 Gene: EEF1A1 |
UniProt ID | P68104 (EF1A1_HUMAN) |
GO terms | GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006412 translation
GO:0006414 translational elongation
GO:0071364 cellular response to epidermal growth factor stimulus
GO:1904714 regulation of chaperone-mediated autophagy
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019901 protein kinase binding
GO:0044822 poly(A) RNA binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005853 eukaryotic translation elongation factor 1 complex
GO:0016020 membrane
GO:0030864 cortical actin cytoskeleton
GO:0032587 ruffle membrane
GO:0070062 extracellular exosome
GO:0098574 cytoplasmic side of lysosomal membrane
GO:0005634 nucleus |
Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
Sequence length | 462 amino acids |
FASTA sequence | >sp|P68104|EF1A1_HUMAN Elongation factor 1-alpha 1 OS=Homo sapiens GN=EEF1A1 PE=1 SV=1
MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPPLGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK |
Structure Information |
PDB ID | None, closest homologue is from Oryctolagus cuniculus, 92.19% Chain A, Elongation Factor 1-alpha 2 4C0S_A |
Quaternary structure | |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1-7, 128-129, 222, 325-333, 383-390, 445-462 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | translation elongation factor |
References for function | |
E.C. number | |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |
Function 2 |
Function description | binds and severs microtubules |
References for function | Shiina N, Gotoh Y, Kubomura N, Iwamatsu A, Nishida E. Microtubule severing by elongation factor 1 alpha. Science. 1994 266(5183):282-5. PMID: 7939665. |
E.C. number | |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |