| General Information |
| MoonProt ID | 320 |
| First appeared in release | 2.0 |
| Name(s) | EF-1alpha, elongation factor 1-alpha |
| UniProt ID | Q95VF2 (Q95VF2_LEIDO) |
| GO terms | GO:0006414 translational elongation
GO:0000166 nucleotide binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Leishmania donovani |
| Sequence length | 449 amino acids |
| FASTA sequence | >tr|Q95VF2|Q95VF2_LEIDO Elongation factor 1-alpha (Fragment) OS=Leishmania donovani PE=2 SV=1
MGKDKVHMNLVVVGHVDAGKSTATGHLIYKCGGIDKRTIEKFEKEAAEIGKASFKYAWVLDKLKAERERGITIDIALWKFESPKSVFTIIDAPGHRDFIKNMITGTSQADAAILMIDSTHGGFEAGISKDGQTREHALLAFTLGVKQMVVCCNKMDDKTVTYAQSRYDEISKEVGAYLKRVGYNPEKVRFIPISGWQGDNMIERSDNMPWYKGPTLLDALDMLEPPVRPVDKPLRLPLQDVYKIGGIGTVPVGRVETGIMKPGDVVTFAPANVTTEVKSIEMHHEQLAEAQPGDNVGFNVKNVSVKDIRRGNVCGNSKNDPPKEAADFTAQVIVLNHPGQISNGYAPVLDCHTSHIACRFAEIESKIDRRSGKELEKNPKAIKSGDAAIVKMVPQKPMCVEVFNDYAPLGRFAVRDMRQTVAVGIIKGVNKKEGSGGKVTKAAAKAAKK |
| Structure Information |
| PDB ID | "None, closest homologue is from Oryctolagus cuniculus, 75.22% Chain A, Elongation Factor 1-alpha 2 4C0S_A" |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-7, 46-50, 127-128, 315-319, 371-381, 435-453 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | translation elongation factor, the rate and fidelity of protein translation |
| References for function | |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds to and activates Src homology 2 domain containing tyrosine phosphatase-1 (SHP-1) in host macrophages, inhibits activity of infected macrophages |
| References for function | 12384497 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | secreted, acts in host cells |
| Comments | |