General Information |
MoonProt ID | 340 |
First appeared in release | 2.0 |
Name(s) | GAPDH, glyceraldehyde-3-phosphate dehydrogenase, Gene: GAPDH |
UniProt ID | D9IL10 (D9IL10_HAECO) |
GO terms | GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
GO:0055114 oxidation-reduction process
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0051287 NAD binding |
Organisms for which functions have been demonstrated | Haemonchus contortus (Barber pole worm) |
Sequence length | 341 amino acids |
FASTA sequence | >tr|D9IL10|D9IL10_HAECO Glyceraldehyde-3-phosphate dehydrogenase OS=Haemonchus contortus GN=GAPDH PE=2 SV=1
MVKPKVGINGCGRIGRLVLRAAVEKEPAEVVAVNDPFINIDYMVYLFKYDSTHGRFKGTVAHEGEHLVVSKEGKSTHRIKVHNSKDPAEIKWGADGAEYIVESTGVFTTVEKASAHLKGGAKKVVISAPSADAPMFVMGVNHETYNAANNHIISNASCTTNCLAPLAKVINDNFGIIEGLMTTVHATTATQKTVDGPSGKLWRDGRGAAQNIIPASTGAAKAVGKVIPTLNGKLTGMAFRVPTPDVSVVDLTCRLEKPASMDDIKKVIKSAADGPMKGILGYTEDQVVSTDFVSDTHSSIFDAGACISLNPNFVKLISWYDNEYGYSHRVVDLLAYIASKA |
Structure Information |
PDB ID | None, but some are available from homologues |
Quaternary structure | |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1-3, 338-341 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | GAPDH, glyceraldehyde-3-phosphate dehydrogenase, in glycolysis, D-glyceraldehyde 3-phosphate + phosphate + NAD+ -> 3-phospho-D-glyceroyl phosphate + NADH |
References for function | 23927077 |
E.C. number | 1.2.1.12 |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |
Function 2 |
Function description | binding alternative complement pathway protein C3, inhibit complement cascade, evade host immunity |
References for function | 23927077 |
E.C. number | |
Location of functional site(s) | |
Cellular location of function | cell surface |
Comments | nematode species infects sheep and goats gastrointestinal tract |