| General Information |
| MoonProt ID | 355 |
| First appeared in release | 2.0 |
| Name(s) | HADHB, (hydroxyacyl-CoA
dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase
(trifunctional protein) beta -subunit, Trifunctional enzyme subunit beta, mitochondrial, Acetyl-CoA acyltransferase, TP-beta, Beta-ketothiolase, Gene: HADHB |
| UniProt ID | P55084 (ECHB_HUMAN) |
| GO terms | GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0008152 metabolic process
GO:0035965 cardiolipin acyl-chain remodeling
GO:0003824 catalytic activity
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity
GO:0003988 acetyl-CoA C-acyltransferase activity
GO:0004300 enoyl-CoA hydratase activity
GO:0005515 protein binding
GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0044822 poly(A) RNA binding
GO:0005739 mitochondrion
GO:0005740 mitochondrial envelope
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0042645 mitochondrial nucleoid
GO:0070062 extracellular exosome |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 474 amino acids |
| FASTA sequence | >sp|P55084|ECHB_HUMAN Trifunctional enzyme subunit beta, mitochondrial OS=Homo sapiens GN=HADHB PE=1 SV=3
MTILTYPFKNLPTASKWALRFSIRPLSCSSQLRAAPAVQTKTKKTLAKPNIRNVVVVDGVRTPFLLSGTSYKDLMPHDLARAALTGLLHRTSVPKEVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRKMRKLMLDLNKAKSMGQRLSLISKFRFNFLAPELPAVSEFSTSETMGHSADRLAAAFAVSRLEQDEYALRSHSLAKKAQDEGLLSDVVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKPYGTVTAANSSFLTDGASAMLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAENYMGRKTKVGLPPLEKFNNWGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK |
| Structure Information |
| PDB ID | |
| Quaternary structure | part of multienzyme complex composed of four alpha-subunits (HADHA) with enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase activities and four beta-subunits (HADHB) with 3-ketoacyl-CoA thiolase activity |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-15, 25-47, 473-474 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, 3-ketoacyl-CoA thiolase activity |
| References for function | |
| E.C. number | 2.3.1.16 |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |
| Function 2 |
| Function description | RNA binding, binds 3'UTR of REN mRNA which results in regulation of renin expression, destabilizes REN mRNA |
| References for function | Adams DJ, Beveridge DJ, van der Weyden L, Mangs H, Leedman PJ, Morris BJ.HADHB, HuR, and CP1 bind to the distal 3'-untranslated region of human renin mRNA and differentially modulate renin expression. J Biol Chem. 2003 Nov 7;278(45):44894-903. PMID: 12933794 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |