| General Information |
| MoonProt ID | 356 |
| First appeared in release | 2.0 |
| Name(s) | Hal3, thymidylate synthase, phosphopantothenoylcysteine decarboxylase, PPCDC, Gene: SPAC15E1.04 |
| UniProt ID | Q9UTI7 (TYSY_SCHPO) |
| GO terms | GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation
GO:0003824 catalytic activity
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0016740 transferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0005737 cytoplasm
GO:0005829 cytosol |
| Organisms for which functions have been demonstrated | Schizosaccharomyces pombe |
| Sequence length | 625 amino acids |
| FASTA sequence | >sp|Q9UTI7|TYSY_SCHPO Probable thymidylate synthase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC15E1.04 PE=3 SV=1
MSQPLHARFATRAVKNPMILEKERQLTDSKYHILVAATGSVAAIKLTLIVKSLLTYKGVDVQVVLTDPARNFVEKEDLTALGVNVYNNADDWKNWDGLECPITHIELRRWAHLLLIAPLSANTMAKMANGLCDNLLTSLIRAWAPLKPILLAPAMNTLMWTNPITQEHLSAISRIYKNSEFIMPIEKVLACGDIGMGGMAEWRNIVGRVADKLQLEQKSVLPNAVKNIDGQDDDSSEQTAAFEEYDDDDDDDVDDNEQSNSMIETSANADITPKASLLPSTTESSISKDHETSQAPLGSESVDTQASENVTTKPEPPVPFTSSEYRNTEEEQYLNLIRYILENGQSRPDRTGTGTRSVFAPPQLRFSLRNNTLPLLTTKRVFLRGVLEELLWFIHGDTNANHLSEKGIHIWDGNGSREFLDSRGLTDRKVGDLGPIYGFQWRHFGAQYVDCDTDYTNKGVDQLAQVISTLKLNPYDRRIILSAWNPLAIPEMALPPCHIFCQFYVSEPCKPGGKPQLSSMMYQRSADMGLGVPFNIASYSLLTHMIAHMCGYEAAEFVHVMGDCHIYNDHLEALQTQLERVPKAFPKLFFKRDAKDIGSIDSFSVDDFAVEGYNPYGPIKMKMSV |
| Structure Information |
| PDB ID | None, some structures of homologues of TS domain available |
| Quaternary structure | hetero and homo trimers |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-15, 25-47, 473-474 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | phosphopantothenoylcysteine decarboxylase, decarboxylation of phosphopahtothenoyl-L-cysteine, in CoA biosynthesis, PPCDC |
| References for function | 23962284 |
| E.C. number | 4.1.1.36 |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |
| Function 2 |
| Function description | inhibitor of serine/threoinine phosphatase Pzh1 |
| References for function | 23962284 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |