Protein Information

General Information
MoonProt ID356
First appeared in release2.0
Name(s)Hal3, thymidylate synthase, phosphopantothenoylcysteine decarboxylase, PPCDC, Gene: SPAC15E1.04
UniProt IDQ9UTI7 (TYSY_SCHPO)
GO termsGO:0006231 dTMP biosynthetic process GO:0006235 dTTP biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0032259 methylation GO:0003824 catalytic activity GO:0004799 thymidylate synthase activity GO:0008168 methyltransferase activity GO:0016740 transferase activity GO:0050660 flavin adenine dinucleotide binding GO:0005737 cytoplasm GO:0005829 cytosol
Organisms for which functions have been demonstratedSchizosaccharomyces pombe
Sequence length625 amino acids
FASTA sequence>sp|Q9UTI7|TYSY_SCHPO Probable thymidylate synthase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC15E1.04 PE=3 SV=1 MSQPLHARFATRAVKNPMILEKERQLTDSKYHILVAATGSVAAIKLTLIVKSLLTYKGVDVQVVLTDPARNFVEKEDLTALGVNVYNNADDWKNWDGLECPITHIELRRWAHLLLIAPLSANTMAKMANGLCDNLLTSLIRAWAPLKPILLAPAMNTLMWTNPITQEHLSAISRIYKNSEFIMPIEKVLACGDIGMGGMAEWRNIVGRVADKLQLEQKSVLPNAVKNIDGQDDDSSEQTAAFEEYDDDDDDDVDDNEQSNSMIETSANADITPKASLLPSTTESSISKDHETSQAPLGSESVDTQASENVTTKPEPPVPFTSSEYRNTEEEQYLNLIRYILENGQSRPDRTGTGTRSVFAPPQLRFSLRNNTLPLLTTKRVFLRGVLEELLWFIHGDTNANHLSEKGIHIWDGNGSREFLDSRGLTDRKVGDLGPIYGFQWRHFGAQYVDCDTDYTNKGVDQLAQVISTLKLNPYDRRIILSAWNPLAIPEMALPPCHIFCQFYVSEPCKPGGKPQLSSMMYQRSADMGLGVPFNIASYSLLTHMIAHMCGYEAAEFVHVMGDCHIYNDHLEALQTQLERVPKAFPKLFFKRDAKDIGSIDSFSVDDFAVEGYNPYGPIKMKMSV
Structure Information
PDB IDNone, some structures of homologues of TS domain available
Quaternary structurehetero and homo trimers
SCOPNA
CATHNA
TM Helix Predictionno TM helices
DisProt AnnotationNot in DisProt
Predicted Disorder Regions1-15, 25-47, 473-474
Connections to Disease
OMIM ID
Function 1
Function descriptionphosphopantothenoylcysteine decarboxylase, decarboxylation of phosphopahtothenoyl-L-cysteine, in CoA biosynthesis, PPCDC
References for function23962284
E.C. number4.1.1.36
Location of functional site(s)
Cellular location of function
Comments
Function 2
Function descriptioninhibitor of serine/threoinine phosphatase Pzh1
References for function23962284
E.C. number
Location of functional site(s)
Cellular location of function
Comments