| General Information |
| MoonProt ID | 362 |
| First appeared in release | 2.0 |
| Name(s) | Hsp60, 60 kDa heat shock protein, mitochondrial Gene: Hsp60 |
| UniProt ID | O02649 (CH60_DROME) |
| GO terms | GO:0006457 protein folding
GO:0006458 'de novo' protein folding
GO:0006626 protein targeting to mitochondrion
GO:0007005 mitochondrion organization
GO:0009408 response to heat
GO:0034605 cellular response to heat
GO:0042026 protein refolding
GO:0009408 response to heat
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0051082 unfolded protein binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005811 lipid particle
GO:0005875 microtubule associated complex |
| Organisms for which functions have been demonstrated | Saccharomyces cerevisiae (yeast, fungi) |
| Sequence length | 573 amino acids |
| FASTA sequence | >sp|O02649|CH60_DROME 60 kDa heat shock protein, mitochondrial OS=Drosophila melanogaster GN=Hsp60 PE=1 SV=3
MFRLPVSLARSSISRQLAMRGYAKDVRFGPEVRAMMLQGVDVLADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKSIELKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISKGANPVEIRRGVMLAVETVKDNLKTMSRPVSTPEEIAQVATISANGDQAIGNLISEAMKKVGRDGVITVKDGKTLTDELEVIEGMKFDRGYISPYFINSSKGAKVEFQDALLLLSEKKISSVQSIIPALELANAQRKPLVIIAEDIDGEALSTLVVNRLKIGLQVAAVKAPGFGDNRKSTLTDMAIASGGIVFGDDADLVKLEDVKVSDLGQVGEVVITKDDTLLLKGKGKKDDVLRRANQIKDQIEDTTSEYEKEKLQERLARLASGVALLRVGGSSEVEVNEKKDRVHDALNATRAAVEEGIVPGGGTALLRCIEKLEGVETTNEDQKLGVEIVRRALRMPCMTIAKNAGVDGAMVVAKVENQAGDYGYDALKGEYGNLIEKGIIDPTKVVRTAITDASGVASLLTTAEAVVTEIPKEDGAPAMPGMGGMGGMGGMGGMGGMM |
| Structure Information |
| PDB ID | None, but structures of homologues from other specieis are available |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-16, 374-380, 550-573 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | chaperonin |
| References for function | |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | mitochondria |
| Comments | |
| Function 2 |
| Function description | binds DNA, bind the template strand of active mtDNA ori sequences in vitro, involved in structure and transmission of mitochondrial DNA nucleoids to daughter cells |
| References for function | Kaufman, B.A., Kolesar, J.E., Perlman, P.S. and Butow, R.A. (2003) A function for the mitochondrial chaperonin Hsp60 in the structure and transmission of mitochondrial DNA nucleoids in Saccharomyces cerevisiae. J. Cell Biol. 163, 457–461. PMID: 14597775 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | mitochondria |
| Comments | |