| General Information |
| MoonProt ID | 364 |
| First appeared in release | 2.0 |
| Name(s) | Inositol-pentakisphosphate 2-kinase, inositol 1,3,4,5,6-pentakisphosphate 2-kinase, Gene: IPPK |
| UniProt ID | Q9H8X2 (IPPK_HUMAN) |
| GO terms | GO:0016310 phosphorylation
GO:0032958 inositol phosphate biosynthetic process
GO:0043647 inositol phosphate metabolic process
GO:0052746 inositol phosphorylation
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0035299 inositol pentakisphosphate 2-kinase activity
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 491 amino acids |
| FASTA sequence | >sp|Q9H8X2|IPPK_HUMAN Inositol-pentakisphosphate 2-kinase OS=Homo sapiens GN=IPPK PE=1 SV=1
MEEGKMDENEWGYHGEGNKSLVVAHAQRCVVLRFLKFPPNRKKTSEEIFQHLQNIVDFGKNVMKEFLGENYVHYGEVVQLPLEFVKQLCLKIQSERPESRCDKDLDTLSGYAMCLPNLTRLQTYRFAEHRPILCVEIKPKCGFIPFSSDVTHEMKHKVCRYCMHQHLKVATGKWKQISKYCPLDLYSGNKQRMHFALKSLLQEAQNNLKIFKNGELIYGCKDARSPVADWSELAHHLKPFFFPSNGLASGPHCTRAVIRELVHVITRVLLSGSDKGRAGTLSPGLGPQGPRVCEASPFSRSLRCQGKNTPERSGLPKGCLLYKTLQVQMLDLLDIEGLYPLYNRVERYLEEFPEERKTLQIDGPYDEAFYQKLLDLSTEDDGTVAFALTKVQQYRVAMTAKDCSIMIALSPCLQDASSDQRPVVPSSRSRFAFSVSVLDLDLKPYESIPHQYKLDGKIVNYYSKTVRAKDNAVMSTRFKESEDCTLVLHKV |
| Structure Information |
| PDB ID | |
| Quaternary structure | |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-7, 40-46, 173-174, 246-249, 273-311, 353-366, 415-421, 469-479, 488-491 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | kinase, ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate => ADP + 1D-myo-inositol hexakisphosphate. |
| References for function | |
| E.C. number | 2.7.1.158 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | scaffold, binds protein kinase CK2, TCOF1, and upstream-binding-factor (UBF) |
| References for function | Brehm MA1, Wundenberg T, Williams J, Mayr GW, Shears SB. A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA. J Cell Sci. 2013 Jan 15;126(Pt 2):437-44. doi: 10.1242/jcs.110031. PMID: 23203802. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | nucleus, nucleolus |
| Comments | |