General Information |
MoonProt ID | 365 |
First appeared in release | 2.0 |
Name(s) | lactate dehydrogenase isozyme M, LDH M, L-lactate dehydrogenase A chain, LDH muscle subunit, LDH-M, LDH-A, Gene: Ldha |
UniProt ID | P06151 (LDHA_MOUSE) |
GO terms | GO:0005975 carbohydrate metabolic process
GO:0019244 lactate biosynthetic process from pyruvate
GO:0019661 glucose catabolic process to lactate via pyruvate
GO:0019752 carboxylic acid metabolic process
GO:0031668 cellular response to extracellular stimulus
GO:0055114 oxidation-reduction process
GO:0003824 catalytic activity
GO:0004457 lactate dehydrogenase activity
GO:0004459 L-lactate dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
GO:0035686 sperm fibrous sheath
GO:0070062 extracellular exosome |
Organisms for which functions have been demonstrated | Mus musculus (Mouse, mammal) |
Sequence length | 332 amino acids |
FASTA sequence | >sp|P06151|LDHA_MOUSE L-lactate dehydrogenase A chain OS=Mus musculus GN=Ldha PE=1 SV=3
MATLKDQLIVNLLKEEQAPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLKTPKIVSSKDYCVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNIVKYSPHCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWVLGEHGDSSVPVWSGVNVAGVSLKSLNPELGTDADKEQWKEVHKQVVDSAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPISTMIKGLYGINEDVFLSVPCILGQNGISDVVKVTLTPEEEARLKKSADTLWGIQKELQF |
Structure Information |
PDB ID | None, but rat, human, rabbit in PDB |
Quaternary structure | tetramer |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1-11 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | enzyme, lactate + NAD+ -> pyruvate + NADH |
References for function | |
E.C. number | 1.1.1.27 |
Location of functional site(s) | Rossman fold |
Cellular location of function | cytoplasm |
Comments | upregulation of LDH seen in some cancers, but not clear which function (or both) involved |
Function 2 |
Function description | RNA binding protein, post-transcriptional regulation of gene expression, AU-rich element (ARE, binding to these kinds of elements can be involved in affecting RNA stability) binding protein (AUBP), role may also involve binding to AUF1 protein, binds the 3 -UTR of GM-CSF RNA |
References for function | 12107167 |
E.C. number | |
Location of functional site(s) | Rossman fold also involved in this function, so probably cannot perform both functions simultaneously, binding to RNA competed by NAD+ |
Cellular location of function | |
Comments | |