| General Information |
| MoonProt ID | 366 |
| First appeared in release | 2.0 |
| Name(s) | lactate dehydrogenase isozyme M, LDH M, L-lactate dehydrogenase A chain, LDH muscle subunit, LDH-M, LDH-A, Gene: Ldha |
| UniProt ID | P06151 (LDHA_MOUSE) |
| GO terms | GO:0005975 carbohydrate metabolic process
GO:0019244 lactate biosynthetic process from pyruvate
GO:0019661 glucose catabolic process to lactate via pyruvate
GO:0019752 carboxylic acid metabolic process
GO:0031668 cellular response to extracellular stimulus
GO:0055114 oxidation-reduction process
GO:0003824 catalytic activity
GO:0004457 lactate dehydrogenase activity
GO:0004459 L-lactate dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016020 membrane
GO:0035686 sperm fibrous sheath
GO:0070062 extracellular exosome |
| Organisms for which functions have been demonstrated | Mus musculus (Mouse, mammal) |
| Sequence length | 332 amino acids |
| FASTA sequence | >sp|P06151|LDHA_MOUSE L-lactate dehydrogenase A chain OS=Mus musculus GN=Ldha PE=1 SV=3
MATLKDQLIVNLLKEEQAPQNKITVVGVGAVGMACAISILMKDLADELALVDVMEDKLKGEMMDLQHGSLFLKTPKIVSSKDYCVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNIVKYSPHCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWVLGEHGDSSVPVWSGVNVAGVSLKSLNPELGTDADKEQWKEVHKQVVDSAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPISTMIKGLYGINEDVFLSVPCILGQNGISDVVKVTLTPEEEARLKKSADTLWGIQKELQF |
| Structure Information |
| PDB ID | None, but rat, human, rabbit in PDB |
| Quaternary structure | tetramer |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-11 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, lactate + NAD+ -> pyruvate + NADH |
| References for function | |
| E.C. number | 1.1.1.27 |
| Location of functional site(s) | Rossman fold |
| Cellular location of function | cytoplasm |
| Comments | upregulation of LDH seen in some cancers, but not clear which function (or both) involved |
| Function 2 |
| Function description | RNA binding protein, post-transcriptional regulation of gene expression, AU-rich element (ARE, binding to these kinds of elements can be involved in affecting RNA stability) binding protein (AUBP), role may also involve binding to AUF1 protein, binds the 3 -UTR of GM-CSF RNA |
| References for function | 12107167 |
| E.C. number | |
| Location of functional site(s) | Rossman fold also involved in this function, so probably cannot perform both functions simultaneously, binding to RNA competed by NAD+ |
| Cellular location of function | |
| Comments | |