| General Information |
| MoonProt ID | 376 |
| First appeared in release | 2.0 |
| Name(s) | phosphoglycerate kinase, Gene: pgk |
| UniProt ID | Q7WTU1 (PGK_SPICI) |
| GO terms | GO:0006096 glycolytic process
GO:0016310 phosphorylation
GO:0000166 nucleotide binding
GO:0004618 phosphoglycerate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Spiroplasma citri, a plant bacterial pathogen transmitted by insects |
| Sequence length | 412 amino acids |
| FASTA sequence | >sp|Q7WTU1|PGK_SPICI Phosphoglycerate kinase OS=Spiroplasma citri GN=pgk PE=3 SV=1
MTNKKELKDVQVKGKKVLVRVDFNVPMKDGQVTDDNRIIAALPTIKYLIAQEAKVILFSHLGKVKTADDLEKRDMAPVAKVLEQKLGQPVKFINAFEGKQLEEAINEMHNKEVILFQNTRFADIINSNGQISVDSEGKAAAKRESKNDSALGKYWASLGDVFVNDAFGTAHRAHASNVGIAENITESCLGFLVEKEVKMLSQCVDNPVKPFVAIIGGAKVSDKIGVIEHLLTKADKILIGGGMAYTFFAAQGHKIGNSLLEVDKVEIAKTFLAKGQGKIILPIDALEAPEFADVPAKVTTGFDIDDGYMGLDIGPKTIELFKKELADAKTVTWNGPMGVFEFKNYSIGTKAVCEAIAELKGAFTLIGGGDSAAAAIQLGYKDKFTHISTGGGASLEYMEGKPLPGIEAVQSK |
| Structure Information |
| PDB ID | None, closest homologues are around 57% amino acid sequence identity |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-3, 67-70, 131-146, 408, 410-412 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, phosphoglycerate kinase, in glycolysis, ATP + 3-phospho-D-glycerate -> ADP + 3-phospho-D-glyceroyl phosphate |
| References for function | |
| E.C. number | 2.7.2.3 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binding to actin filament in insect vector (Circulifer haemotoceps, leafhopper) during invasion |
| References for function | Labroussaa, F., Arricau-Bouvery, N., Dubrana, M.P. and Saillard, C.
(2010) Entry of Spiroplasma citri into Circulifer haematoceps cells
involves interaction between Spiroplasma phosphoglycerate kinase
and leafhopper actin. Appl. Environ. Microbiol. 76, 1879–1886. 10.1128/AEM.02384-09. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |