| General Information |
| MoonProt ID | 382 |
| First appeared in release | 2.0 |
| Name(s) | pyruvate kinase 1, cell division cycle protein 19, Gene name: CDC19, PYK1 |
| UniProt ID | P00549 (KPYK1_YEAST) |
| GO terms | GO:0006090 pyruvate metabolic process
GO:0006096 glycolytic process
GO:0008152 metabolic process
GO:0016310 phosphorylation
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0030955 potassium ion binding
GO:0046872 metal ion binding
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Saccharomyces cerevisiae (yeast, fungi) |
| Sequence length | 500 amino acids |
| FASTA sequence | >sp|P00549|KPYK1_YEAST Pyruvate kinase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC19 PE=1 SV=2
MSRLERLTSLNVVAGSDLRRTSIIGTIGPKTNNPETLVALRKAGLNIVRMNFSHGSYEYHKSVIDNARKSEELYPGRPLAIALDTKGPEIRTGTTTNDVDYPIPPNHEMIFTTDDKYAKACDDKIMYVDYKNITKVISAGRIIYVDDGVLSFQVLEVVDDKTLKVKALNAGKICSHKGVNLPGTDVDLPALSEKDKEDLRFGVKNGVHMVFASFIRTANDVLTIREVLGEQGKDVKIIVKIENQQGVNNFDEILKVTDGVMVARGDLGIEIPAPEVLAVQKKLIAKSNLAGKPVICATQMLESMTYNPRPTRAEVSDVGNAILDGADCVMLSGETAKGNYPINAVTTMAETAVIAEQAIAYLPNYDDMRNCTPKPTSTTETVAASAVAAVFEQKAKAIIVLSTSGTTPRLVSKYRPNCPIILVTRCPRAARFSHLYRGVFPFVFEKEPVSDWTDDVEARINFGIEKAKEFGILKKGDTYVSIQGFKAGAGHSNTLQVSTV |
| Structure Information |
| PDB ID | 1A3W |
| Quaternary structure | |
| SCOP | PK beta-barrel domain-like, TIM beta/alpha-barrel, Pyruvate kinase C-terminal domain-like |
| CATH | 3.40.1380.20, 3.20.20.60, 2.40.33.10 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-15, 370-376 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | pyruvate kinase, ATP + pyruvate <=> ADP + phosphoenolpyruvate. |
| References for function | |
| E.C. number | 2.7.1.40 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | histone kinase, phosphorylates H3T11, protein kinase, part of SESAME complex |
| References for function | 26527276 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | |