| General Information |
| MoonProt ID | 394 |
| First appeared in release | 2.0 |
| Name(s) | triosephosphate isomerase, TIM,, Gene: TPI1 |
| UniProt ID | P60174 (TPIS_HUMAN) |
| GO terms | GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0006098 pentose-phosphate shunt
GO:0007275 multicellular organism development
GO:0008152 metabolic process
GO:0019563 glycerol catabolic process
GO:0019682 glyceraldehyde-3-phosphate metabolic process
GO:0046166 glyceraldehyde-3-phosphate biosynthetic process
GO:0061621 canonical glycolysis
GO:0003824 catalytic activity
GO:0004807 triose-phosphate isomerase activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0031625 ubiquitin protein ligase binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005829 cytosol
GO:0070062 extracellular exosome |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 286 amino acids |
| FASTA sequence | >sp|P60174|TPIS_HUMAN Triosephosphate isomerase OS=Homo sapiens GN=TPI1 PE=1 SV=3
MAEDGEEAEFHFAALYISGQWPRLRADTDLQRLGSSAMAPSRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPADTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPEFVDIINAKQ |
| Structure Information |
| PDB ID | 4POC, 1WYI, 1HTI, 4BR1 |
| Quaternary structure | |
| SCOP | TIM beta/alpha-barrel |
| CATH | 3.20.20.70 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-11, 30-33, 284-286 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | triosephosphate isomerase, D-glyceraldehyde 3-phosphate <-> dihydroxyacetone phosphate, in glycolysis and gluconeogenesis |
| References for function | |
| E.C. number | 5.3.1.1 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | interact with rhZP3 and rhZP4, interactions with zona pellucida proteins of egg |
| References for function | 23355646, 15236338 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | head of sperm, sperm membrane |
| Comments | |