| General Information |
| MoonProt ID | 399 |
| First appeared in release | 4.0 |
| Name(s) | alpha-actinin-3 |
| UniProt ID | X5FVA1 |
| GO terms | GO:0003779 actin binding
GO:0005509 calcium ion binding
GO:0005768 endosome |
| Organisms for which functions have been demonstrated | Trichomonas vaginalis |
| Sequence length | 1129 |
| FASTA sequence | >tr|X5FVA1|X5FVA1_TRIVA Alpha actinin-3 OS=Trichomonas vaginalis OX=5722 GN=actn3 PE=4 SV=1
MSNNRGLLDDAWEQTQIKVFSRWTAKQLSFKGIPFDNVLEEFADGVKLIQLLEIVSKEPM
KGKWHKQPKMRVQMRENCGMALDFISSKNIRMVGIGSDDIIDKNKKLTLGLIWTIINKFM
IEEISVEEATARDALLLWAKKNTQGYKGVNVTNFTTSWSDGLAFCALINKFRPNMLDYDS
LDQTQQKENCEKAFAACKELGIYVFLDPEDLVGTQPDEKSVVTQVAEFFHFFAGESKTQA
AADKLKRTIGIQKAIEEEALNYEKQAQECLDVINTEREKLLAQDYDQTVPGVKSKLFNCI
KFGRVVRPVIVDKRGVAMKTWGQLVTKCNSNGRPIPQVKEELLPPTLNLKFEEIEKTASD
RRDELTKILEELQAKLINAFDEAANAKIAVCDDINNKAINLTGDLYEQRDALNNYLQQAQ
EAAGTVKELQPQFVELVELRLNNRVKRTVIAVDGEFEQLIATIKRLIEGNKAAIFEYENK
KKIEEYNQAAQKYVDEVAQLKQDLEAIAGELREQRAANVDKSEEIIQKRNGVSDIRPMFQ
ELEKQSLHLGIENTPDAVTAMYTACLSQAQDKITQISKQLVDEYNEKAIAIHEKIGDVHK
TADSVSGTTQEKKDGALKCQSDLTEIKASIQPTLEEPYQYLQSIKYSNAVKYTPNDLTRD
SDITFAFLTTLLNQLEEQLQSESNDARIAAYNELATKYVDIANEFHQKVSTIDGDRATRR
NAYLSAQLELGNKREGLSQLKPEYEALERDTLHIRVNDSPATISKVYANALQIITDKLAE
IYNEMVADFDAQVLAIAEKVKVVQNVELTGTLLELKDKIAQSKAQAQEILPELPTLDAPW
EDLCDFNLNYRVKQTPENLRATLEAVIAFLNHQEESNNEKLASEGRESRIFAYNQKAAVS
VALARELEQKVSNVDGTLPEKQQKLFDIKQEVIDGDEAAKELTPIFEDLEKDELHLAIED
TPDSIAAFFANILSHIDGLVREIDTAIAAEKGLQISEEQLTEFRETFNHFDKDHTNFLQY
FELRACLTALGDDISDDQAKEVCKKYSATGEEKLNFDEYVKFMLDHFSKAENADTTAKAF
KAIANNNPILTDAQLDQYFKGEEAEYLRKVLKQVDGGYEFAEWVNSIYA |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | binds and crosslinks actin |
| References for function | Figueroa-Angulo EE, Calla-Choque JS, Mancilla-Olea MI, Arroyo R. RNA-Binding Proteins in Trichomonas vaginalis: Atypical Multifunctional Proteins. Biomolecules. 2015 Nov 26;5(4):3354-95. doi: 10.3390/biom5043354. PMID: 26703754; PMCID: PMC4693282. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds RNA to regulate translation |
| References for function | Figueroa-Angulo EE, Calla-Choque JS, Mancilla-Olea MI, Arroyo R. RNA-Binding Proteins in Trichomonas vaginalis: Atypical Multifunctional Proteins. Biomolecules. 2015 Nov 26;5(4):3354-95. doi: 10.3390/biom5043354. PMID: 26703754; PMCID: PMC4693282. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |