| General Information |
| MoonProt ID | 40 |
| First appeared in release | 1.0 |
| Name(s) | enolase
Alpha-enolase
2-phospho-D-glycerate hydro-lyase
C-myc promoter-binding protein
Enolase 1
MBP-1
MPB-1
ENO1L1, MBPB1, MPB1
Non-neural enolase
NNE
Phosphopyruvate hydratase
Plasminogen-binding protein
Gene Name: ENO1
|
| UniProt ID | P06733 (ENOA_HUMAN), Reviewed |
| GO terms | GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0006096 glycolysis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-dependent
GO:0009615 response to virus
GO:0030308 negative regulation of cell growth
GO:0044281 small molecule metabolic process
GO:0045892 negative regulation of transcription, DNA-dependent
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0004634 phosphopyruvate hydratase activity
GO:0005515 protein binding
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0000015 phosphopyruvate hydratase comple
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031430 M band
GO:0070062 extracellular vesicular exosome x |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal, OMIM number 172430 Enolase deficiency) |
| Sequence length | 434 |
| FASTA sequence | >gi|1167843|emb|CAA34360.1| alpha-enolase [Homo sapiens]
MSILKIHAREIFDSRGNPTVEVDLFTSKGLFRAAVPSGASTGIYEALELRDNDKTRYMGKGVSKAVEHINKTIAPALVSKKLNVTEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNSEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAANFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEGLELLKTAIGKAGYTDKVVIGMDVAASEFFRSGKYDLDFKSPDDPSRYISPDQLADLYKSFIKDYPVVSIEDPFDQDDWGAWQKFTASAGIQVVGDDLTVTNPKRIAKAVNEKSCNCLLLKVNQIGSVTESLQACKLAQANGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLLRIEEELGSKAKFAGRNFRNPLAK |
| Structure Information |
| PDB ID | 1TE6
2AKM
2AKZ 3UJE
3UJR
3UJS
3UJF
3UCC
3UCD |
| Quaternary structure | |
| SCOP | Enolase N-terminal domain-like, TIM beta/alpha-barrel |
| CATH | 3.30.390.10, 3.20.20.120 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-4,429-434 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enolase, enzyme
2-phospho-D-glycerate => phosphoenolpyruvate + H2O
Carbohydrate degradation, glycolysis
|
| References for function | enzyme activity was assayed: Miles, L. A., Dahlberg, C. M., Plescia, J., Felez, J., Kato, K. & Plow, E. F. (1991). Role of cell-surface lysines in plasmin(ogen)-binding to cells: identification of alpha-enolase as a candidate plasminogen receptor. Biochemistry. 1991 Feb 12;30(6):1682-91. PMID:
1847072 |
| E.C. number | 4.2.1.11 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | plasminogen binding |
| References for function | Redlitz A, Fowler BJ, Plow EF, Miles LA. The role of an enolase-related molecule in plasminogen binding to cells. Eur J Biochem. 1995 Jan 15;227(1-2):407-15. PMID: 7851415 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |