| General Information |
| MoonProt ID | 4014 |
| First appeared in release | 4.0 |
| Name(s) | Indoleamine 2,3-dioxygenase 1, IDO1 |
| UniProt ID | P14902 |
| GO terms | GO:0046006 regulation of activated T cell proliferation, GO:0002666 positive regulation of T cell tolerance induction, GO:0002678 positive regulation of chronic inflammatory response, GO:0002830 positive regulation of type 2 immune response, GO:0006954 inflammatory response, GO:0032496 response to lipopolysaccharide, GO:0032693 negative regulation of interleukin-10 production, GO:0032735 positive regulation of interleukin-12 production, GO:0033555 multicellular organismal response to stress, GO:0034276 kynurenic acid biosynthetic process, GO:0036269 swimming behavior, GO:0042130 negative regulation of T cell proliferation, GO:0043065 positive regulation of apoptotic process, GO:0070233 negative regulation of T cell apoptotic process, GO:0004833 L-tryptophan 2,3-dioxygenase activity, GO:0009055 electron transfer activity, GO:0016491 oxidoreductase activity, GO:0020037 heme binding, GO:0033754 indoleamine 2,3-dioxygenase activity, GO:0046872 metal ion binding, GO:0051213 dioxygenase activity, GO:0002376 immune system process, GO:0006569 L-tryptophan catabolic process, GO:0007565 female pregnancy, GO:0019441 L-tryptophan catabolic process to kynurenine, GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan, GO:0070234 positive regulation of T cell apoptotic process, GO:0005737 cytoplasm, GO:0005829 cytosol, GO:0030485 smooth muscle contractile fiber, GO:0032421 stereocilium bundle |
| Organisms for which functions have been demonstrated | Homo sapiens (Human) |
| Sequence length | 403 |
| FASTA sequence | ">sp|P14902|I23O1_HUMAN Indoleamine 2,3-dioxygenase 1 OS=Homo sapiens OX=9606 GN=IDO1 PE=1 SV=1
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG" |
| Structure Information |
| PDB ID | 2D0T 2D0U 4PK5 4PK6 4U72 4U74 5EK2 5EK3 5EK4 5ETW 5WHR 5WMU 5WMV 5WMW 5WMX 5WN8 5XE1 6AZU 6AZV 6AZW 6CXU 6CXV 6DPQ 6DPR 6E35 6E40 6E41 6E42 6E43 6E44 6E45 6E46 6F0A 6KOF 6KPS 6KW7 6MQ6 6O3I 6PZ1 6PU7 6R63 6UBP 6V52 6WJY 6WPE 6X5Y 7A62 7AH4 7AH5 7AH6 7B1O 7E0O 7E0P 7E0Q 7E0S 7E0T 7E0U 7M63 7M7D 7NGE 7P0N 7P0R 7RRB 7RRC 7RRD 7YXT 7Z2L 7ZV3 8ABX 8FUR 8I7L 8U5I |
| Quaternary structure | NA |
| SCOP | "80270902D0T A:12-403
80394692D0T A:12-403" |
| CATH | 2d0tA01, 2d0tB01 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, indoleamine 2,3-dioxygenase |
| References for function | _ |
| E.C. number | EC:1.13.11.52 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | nonenzymatic role in protein-protein interactions in signaling pathway |
| References for function | Pallotta MT, Orabona C, Volpi C, Vacca C, Belladonna ML, Bianchi R, Servillo G, Brunacci C, Calvitti M, Bicciato S, Mazza EM, Boon L, Grassi F, Fioretti MC, Fallarino F, Puccetti P, Grohmann U. Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells. Nat Immunol. 2011 Jul 31;12(9):870-8. doi: 10.1038/ni.2077. PMID: 21804557. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |