| General Information |
| MoonProt ID | 4030 |
| First appeared in release | 4.0 |
| Name(s) | Pyruvate kinase PykA |
| UniProt ID | P80885 |
| GO terms | "GO:0000166 nucleotide binding ; GO:0000287 magnesium ion binding ; GO:0003824 catalytic activity ; GO:0004743 pyruvate kinase activity ; GO:0004743 pyruvate kinase activity ; GO:0005524 ATP binding ; GO:0016301 kinase activity ; GO:0016740 transferase activity ; GO:0016772 transferase activity, transferring phosphorus-containing groups ; GO:0030955 potassium ion binding ; GO:0046872 metal ion binding ; GO:0006096 glycolytic process ; GO:0006096 glycolytic process ; GO:0006950 response to stress ; GO:0005737 cytoplasm ; GO:0005829 cytosol " |
| Organisms for which functions have been demonstrated | Bacillus subtilis (strain 168) |
| Sequence length | 585.0 |
| FASTA sequence | ">sp|P80885|KPYK_BACSU Pyruvate kinase OS=Bacillus subtilis (strain 168) OX=224308 GN=pyk PE=1 SV=2
MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHGARIKNIREASKKLGKN
VGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTDKISVTYEGLVHDVEQGST
ILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNVPGVSVNLPGITEKDARDIVF
GIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQIIPKIENQEGVDNIDAILEVSDGL
MVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVITATQMLDSMQRNPRPTRAEASDVAN
AIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASRSEEALNYKEILSKRRDQVGMTITDAI
GQSVAHTAINLNAAAIVTPTESGHTARMIAKYRPQAPIVAVTVNDSISRKLALVSGVFAE
SGQNASSTDEMLEDAVQKSLNSGIVKHGDLIVITAGTVGESGTTNLMKVHTVGDIIAKGQ
GIGRKSAYGPVVVAQNAKEAEQKMTDGAVLVTKSTDRDMIASLEKASALITEEGGLTSHA
AVVGLSLGIPVIVGLENATSILTDGQDITVDASRGAVYQGRASVL" |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, pyruvate kinase, formation of pyruvate and ATP from phosphoenolpyruvate and ADP, glycolysis |
| References for function | _ |
| E.C. number | 2.7.1.40 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds to DnaE polymerase to regulate transcription |
| References for function | Holland A, Pitoulias M, Soultanas P, Janniere L. The Replicative DnaE Polymerase of Bacillus subtilis Recruits the Glycolytic Pyruvate Kinase (PykA) When Bound to Primed DNA Templates. Life (Basel). 2023 Apr 7;13(4):965. doi: 10.3390/life13040965. PMID: 37109494; PMCID: PMC10143966. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | at DNA |
| Comments | |