| General Information |
| MoonProt ID | 4038 |
| First appeared in release | 4.0 |
| Name(s) | serine hydroxymethyl transferase GlyA |
| UniProt ID | Q9Z831 |
| GO terms | GO:0004372 glycine hydroxymethyltransferase activity ; GO:0016740 transferase activity ; GO:0030170 pyridoxal phosphate binding ; GO:0006545 glycine biosynthetic process ; GO:0006730 one-carbon metabolic process ; GO:0008652 amino acid biosynthetic process ; GO:0019264 glycine biosynthetic process from serine ; GO:0035999 tetrahydrofolate interconversion ; GO:0046653 tetrahydrofolate metabolic process ; GO:0005737 cytoplasm ; GO:0005829 cytosol |
| Organisms for which functions have been demonstrated | Chlamydia pneumoniae (Chlamydophila pneumoniae) |
| Sequence length | 497.0 |
| FASTA sequence | ">sp|Q9Z831|GLYA_CHLPN Serine hydroxymethyltransferase OS=Chlamydia pneumoniae OX=83558 GN=glyA PE=3 SV=2
MVSLLHKFLENASGKKGQSLASTAYLAALDHLLNAFPSIGERIIDELKSQRSHLKMIASE
NYSSLSVQLAMGNLLTDKYCEGSPFKRFYSCCENVDAIEWECVETAKELFAADCACVQPH
SGADANLLAVMAILTHKVQGPAVSKLGYKTVNELTEEEYTLLKAEMSSCVCLGPSLNSGG
HLTHGNVRLNVMSKLMRCFPYDVNPDTECFDYAEISRLAKEYKPKVLIAGYSSYSRRLNF
AVLKQIAEDCGSVLWVDMAHFAGLVAGGVFVDEENPIPYADIVTTTTHKTLRGPRGGLVL
ATREYESTLNKACPLMMGGPLPHVIAAKTVALKEALSVDFKKYAHQVVNNARRLAERFLS
HGLRLLTGGTDNHMMVIDLGSLGISGKIAEDILSSVGIAVNRNSLPSDAIGKWDTSGIRL
GTPALTTLGMGIDEMEEVADIIVKVLRNIRLSCHVEGSSKKNKGELPEAIAQEARDRVRN
LLLRFPLYPEIDLEALV" |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | homodimer |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, serine hydroxymethyltransferase |
| References for function | _ |
| E.C. number | E.C. 2.1.2.1 |
| Location of functional site(s) | |
| Cellular location of function | cytoplas, |
| Comments | |
| Function 2 |
| Function description | enzyme, alanine racemase |
| References for function | De Benedetti S, Bühl H, Gaballah A, Klöckner A, Otten C, Schneider T, Sahl HG, Henrichfreise B. Characterization of serine hydroxymethyltransferase GlyA as a potential source of D-alanine in Chlamydia pneumoniae. Front Cell Infect Microbiol. 2014 Feb 26;4:19. doi: 10.3389/fcimb.2014.00019. PMID: 24616885; PMCID: PMC3935232. |
| E.C. number | EC 5.1.1.1 |
| Location of functional site(s) | |
| Cellular location of function | Cytoplasm |
| Comments | |