| General Information |
| MoonProt ID | 405 |
| First appeared in release | 3.0 |
| Name(s) | heat shock protein SSA1, gene: SSA1, HSP70 |
| UniProt ID | P41797 |
| GO terms | GO:0044416 induction by symbiont of host defense response P
GO:0042277 peptide binding F
GO:0005829 cytosol C
GO:0005886 plasma membrane C
GO:0030445 yeast-form cell wall C
GO:0030446 hyphal cell wall C
GO:0051701 interaction with host P
GO:0009986 cell surface C
GO:0009277 fungal-type cell wall C
GO:0009636 response to toxic substance P
GO:0034605 cellular response to heat P
GO:0062040 fungal biofilm matrix C
GO:0044409 entry into host P
GO:0016192 vesicle-mediated transport P
GO:0006986 response to unfolded protein P
GO:0005829 cytosol C
GO:0051787 misfolded protein binding F
GO:0051085 chaperone cofactor-dependent protein refolding P
GO:0051082 unfolded protein binding F
GO:0042026 protein refolding P
GO:0034620 cellular response to unfolded protein P
GO:0031072 heat shock protein binding F
GO:0016887 ATPase activity F
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation P
GO:0005886 plasma membrane C
GO:0005737 cytoplasm C
GO:0005634 nucleus C
GO:0005524 ATP binding F
GO:0044183 protein folding chaperone F
GO:0005576 extracellular region C
GO:0005524 ATP binding F
GO:0005618 cell wall C
GO:0000166 nucleotide binding F
GO:0005737 cytoplasm C
GO:0005886 plasma membrane C
GO:0019730 antimicrobial humoral response P
GO:0005737 cytoplasm C
GO:0005618 cell wall C
|
| Organisms for which functions have been demonstrated | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| Sequence length | 656 amino acids |
| FASTA sequence | >sp|P41797|HSP71_CANAL Heat shock protein SSA1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=SSA1 PE=1 SV=2
MSKAVGIDLGTTYSCVAHFANDRVEIIANDQGNRTTPSFVAFTDTERLIGDAAKNQAAMNPANTVFDAKRLIGRKFDDPEVINDAKHFPFKVIDKAGKPVIQVEYKGETKTFSPEEISSMVLTKMKEIAEGYLGSTVKDAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKGSRGEHNVLIFDLGGGTFDVSLLAIDEGIFEVKATAGDTHLGGEDFDNRLVNFFIQEFKRKNKKDISTNQRALRRLRTACERAKRTLSSSAQTSIEIDSLYEGIDFYTSITRARFEELCADLFRSTLDPVGKVLADAKIDKSQVEEIVLVGGSTRIPKIQKLVSDFFNGKELNKSINPDEAVAYGAAVQAAILTGDTSSKTQDILLLDVAPLSLGIETAGGIMTKLIPRNSTIPTKKSETFSTYADNQPGVLIQVFEGERAKTKDNNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVSALEKGTGKTQKITITNDKGRLSKEEIDKMVSEAEKFKEEDEKEAARVQAKNQLESYAYSLKNTINDGEMKDKIGADDKEKLTKAIDETISWLDASQAASTEEYEDKRKELESVANPIISGAYGAAGGAPGGAGGFPGAGGFPGGAPGAGGPGGATGGESSGPTVEEVD |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | Use FASTA sequence on the MFDp2 webserver.
moonID_405_uniID_P41797 is 656 residues long, with 167 residues (25.46%) predicted as disordered.The protein has 0 short (< 30 residues) disorder segments and 1 long (>= 30 residues) disorder segment.
Segment 1 - Long (>= 30 residues) disordered segment Segment is located between positions 490 and 656 in the sequence. The segment is 167 residues long (25.46 % of the total sequence length). |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | chaperone protein, intracellular function |
| References for function | Sun, J.N.; Solis, N.V.; Phan, Q.T.; Bajwa, J.S.; Kashleva, H.; Thompson, A.; Liu, Y.; Dongari-Bagtzoglou, A.; Edgerton, M.; Filler, S.G. Host cell invasion and virulence mediated by Candida albicans Ssa1. PLoS Pathog. 2010, 6, e1001181. Li, X.S.; Reddy, M.S.; Baev, D.; Edgerton, M. Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5. J. Biol. Chem. 2003, 278, 28553–28561. |
| E.C. number | NA |
| Location of functional site(s) | NA |
| Cellular location of function | intracellular |
| Comments | NA |
| Function 2 |
| Function description | inducing endocytosis, belongs to heat shock protein 70 (Hsp 70) family |
| References for function | Li, X.S.; Reddy, M.S.; Baev, D.; Edgerton, M. Candida albicans Ssa1/2p is the cell envelope binding protein for human salivary histatin 5. J. Biol. Chem. 2003, 278, 28553–28561. |
| E.C. number | NA |
| Location of functional site(s) | NA |
| Cellular location of function | reported to be at the yeast cell wall |
| Comments | latex beads were rapidly endocytosed by oral epithelial and endothelial cells, suggesting its role in virulence |