| General Information |
| MoonProt ID | 4055 |
| First appeared in release | 4.0 |
| Name(s) | Small-conductance mechanosensitive channel - mscS |
| UniProt ID | P0C0S1 |
| GO terms | GO:0005886 plasma membrane, GO:0016020 membrane, GO:0008381 mechanosensitive monoatomic ion channel activity, GO:0009992 intracellular water homeostasis, GO:0034220 monoatomic ion transmembrane transport, GO:0055085 transmembrane transport, GO:0006811 monoatomic ion transport, GO:0042802 identical protein binding, GO:0051260 protein homooligomerization |
| Organisms for which functions have been demonstrated | Escherichia coli (strain K12) |
| Sequence length | 286.0 |
| FASTA sequence | ">sp|P0C0S1|MSCS_ECOLI Small-conductance mechanosensitive channel OS=Escherichia coli (strain K12) OX=83333 GN=mscS PE=1 SV=1
MEDLNVVDSINGAGSWLVANQALLLSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRK
IDATVADFLSALVRYGIIAFTLIAALGRVGVQTASVIAVLGAAGLAVGLALQGSLSNLAA
GVLLVMFRPFRAGEYVDLGGVAGTVLSVQIFSTTMRTADGKIIVIPNGKIIAGNIINFSR
EPVRRNEFIIGVAYDSDIDQVKQILTNIIQSEDRILKDREMTVRLNELGASSINFVVRVW
SNSGDLQNVYWDVLERIKREFDAAGISFPYPQMDVNFKRVKEDKAA" |
| Structure Information |
| PDB ID | 2OAU 2VV5 3UDC 4AGE 4AGF 4HWA 5AJI 6PWN 6PWO 6PWP 6RLD 6UZH 6VYK 6VYL 6VYM 7ONL 7OO0 7OO6 7RAZ 8DDJ |
| Quaternary structure | homoheptamer |
| SCOP | "No SCOP2 classification is available for 2OAU A, B, C, D, E, F, G explicitly. This entry is represented by following domains ...
80254172VV5 A
80254192VV5 A
80254202VV5 A
80377962VV5 A
80377982VV5 A
80377992VV5 A
" |
| CATH | 2oauA01, 2oauA02, 2oauA03, 2oauB01, 2oauB02, 2oauB03, 2oauC01, 2oauC02, 2oauC03, 2oauD01 |
| TM Helix Prediction | 3 |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | mechanosensitive channel |
| References for function | _ |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cell membrane |
| Comments | |
| Function 2 |
| Function description | copper channel |
| References for function | Ghnamah Y, Palmer CD, Livnat-Levanon N, Grupper M, Rosenzweig AC, Lewinson O. Prokaryotic mechanosensitive channels mediate copper influx. Protein Sci. 2025 Jul;34(7):e70205. doi: 10.1002/pro.70205. PMID: 40563205; PMCID: PMC12198049. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cell membrane |
| Comments | |