| General Information |
| MoonProt ID | 4066 |
| First appeared in release | 4.0 |
| Name(s) | Chromatin-remodeling ATPase INO80 |
| UniProt ID | Q9ULG1 |
| GO terms | "GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003677 DNA binding
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0016887 ATP hydrolysis activity
GO:0042393 histone binding
GO:0043014 alpha-tubulin binding
GO:0140658 ATP-dependent chromatin remodeler activity
GO:0000070 mitotic sister chromatid segregation
GO:0000723 telomere maintenance
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0006259 DNA metabolic process
GO:0006275 regulation of DNA replication
GO:0006281 DNA repair
GO:0006281 DNA repair
GO:0006282 regulation of DNA repair
GO:0006282 regulation of DNA repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0006338 chromatin remodeling
GO:0006338 chromatin remodeling
GO:0006338 chromatin remodeling
GO:0006338 chromatin remodeling
GO:0006351 DNA-templated transcription
GO:0006974 DNA damage response
GO:0010571 positive regulation of nuclear cell cycle DNA replication
GO:0030307 positive regulation of cell growth
GO:0033044 regulation of chromosome organization
GO:0033044 regulation of chromosome organization
GO:0034644 cellular response to UV
GO:0045739 positive regulation of DNA repair
GO:0045739 positive regulation of DNA repair
GO:0045893 positive regulation of DNA-templated transcription
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045995 regulation of embryonic development
GO:0045995 regulation of embryonic development
GO:0051054 positive regulation of DNA metabolic process
GO:0051225 spindle assembly
GO:0051276 chromosome organization
GO:0051301 cell division
GO:0051726 regulation of cell cycle
GO:0060382 regulation of DNA strand elongation
GO:0070914 UV-damage excision repair
GO:0071479 cellular response to ionizing radiation
GO:1904507 positive regulation of telomere maintenance in response to DNA damage
GO:1904507 positive regulation of telomere maintenance in response to DNA damage
GO:2000045 regulation of G1/S transition of mitotic cell cycle
GO:0005634 nucleus
GO:0005634 nucleus
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005874 microtubule
GO:0016604 nuclear body
GO:0031011 Ino80 complex
GO:0031011 Ino80 complex
GO:0031011 Ino80 complex
GO:0031011 Ino80 complex
GO:0031011 Ino80 complex" |
| Organisms for which functions have been demonstrated | Homo sapiens (Human) |
| Sequence length | 1556.0 |
| FASTA sequence | ">sp|Q9ULG1|INO80_HUMAN Chromatin-remodeling ATPase INO80 OS=Homo sapiens OX=9606 GN=INO80 PE=1 SV=2
MASELGARDDGGCTELAKPLYLQYLERALRLDHFLRQTSAIFNRNISSDDSEDGLDDSNP
LLPQSGDPLIQVKEEPPNSLLGETSGAGSSGMLNTYSLNGVLQSESKCDKGNLYNFSKLK
KSRKWLKSILLSDESSEADSQSEDDDEEELNLSREELHNMLRLHKYKKLHQNKYSKDKEL
QQYQYYSAGLLSTYDPFYEQQRHLLGPKKKKFKEEKKLKAKLKKVKKKRRRDEELSSEES
PRRHHHQTKVFAKFSHDAPPPGTKKKHLSIEQLNARRRKVWLSIVKKELPKANKQKASAR
NLFLTNSRKLAHQCMKEVRRAALQAQKNCKETLPRARRLTKEMLLYWKKYEKVEKEHRKR
AEKEALEQRKLDEEMREAKRQQRKLNFLITQTELYAHFMSRKRDMGHDGIQEEILRKLED
SSTQRQIDIGGGVVVNITQEDYDSNHFKAQALKNAENAYHIHQARTRSFDEDAKESRAAA
LRAANKSGTGFGESYSLANPSIRAGEDIPQPTIFNGKLKGYQLKGMNWLANLYEQGINGI
LADEMGLGKTVQSIALLAHLAERENIWGPFLIISPASTLNNWHQEFTRFVPKFKVLPYWG
NPHDRKVIRRFWSQKTLYTQDAPFHVVITSYQLVVQDVKYFQRVKWQYMVLDEAQALKSS
SSVRWKILLQFQCRNRLLLTGTPIQNTMAELWALLHFIMPTLFDSHEEFNEWFSKDIESH
AENKSAIDENQLSRLHMILKPFMLRRIKKDVENELSDKIEILMYCQLTSRQKLLYQALKN
KISIEDLLQSSMGSTQQAQNTTSSLMNLVMQFRKVCNHPELFERQETWSPFHISLKPYHI
SKFIYRHGQIRVFNHSRDRWLRVLSPFAPDYIQRSLFHRKGINEESCFSFLRFIDISPAE
MANLMLQGLLARWLALFLSLKASYRLHQLRSWGAPEGESHQRYLRNKDFLLGVNFPLSFP
NLCSCPLLKSLVFSSHCKAVSGYSDQVVHQRRSATSSLRRCLLTELPSFLCVASPRVTAV
PLDSYCNDRSAEYERRVLKEGGSLAAKQCLLNGAPELAADWLNRRSQFFPEPAGGLWSIR
PQNGWSFIRIPGKESLITDSGKLYALDVLLTRLKSQGHRVLIYSQMTRMIDLLEEYMVYR
KHTYMRLDGSSKISERRDMVADFQNRNDIFVFLLSTRAGGLGINLTAADTVIFYDSDWNP
TVDQQAMDRAHRLGQTKQVTVYRLICKGTIEERILQRAKEKSEIQRMVISGGNFKPDTLK
PKEVVSLLLDDEELEKKLRLRQEEKRQQEETNRVKERKRKREKYAEKKKKEDELDGKRRK
EGVNLVIPFVPSADNSNLSADGDDSFISVDSAMPSPFSEISISSELHTGSIPLDESSSDM
LVIVDDPASSAPQSRATNSPASITGSVSDTVNGISIQEMPAAGRGHSARSRGRPKGSGST
AKGAGKGRSRKSTAGSAAAMAGAKAGAAAASAAAYAAYGYNVSKGISASSPLQTSLVRPA
GLADFGPSSASSPLSSPLSKGNNVPGNPKNLHMTSSLAPDSLVRKQGKGTNPSGGR" |
| Structure Information |
| PDB ID | "6HTS
7ZI4" |
| Quaternary structure | NA |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | component of the chromatin remodeling complex |
| References for function | _ |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | |
| Function 2 |
| Function description | binds tubulin and interacts with the mitotic spindle |
| References for function | Park EJ, Hur SK, Lee HS, Lee SA, Kwon J. The human Ino80 binds to microtubule via the E-hook of tubulin: implications for the role in spindle assembly. Biochem Biophys Res Commun. 2011 Dec 16;416(3-4):416-20. doi: 10.1016/j.bbrc.2011.11.069. Epub 2011 Nov 19. PMID: 22133677. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |