| General Information |
| MoonProt ID | 4087 |
| First appeared in release | 4.0 |
| Name(s) | ATP-dependent Clp protease ATP-binding subunit |
| UniProt ID | A0AAN1EZI8 |
| GO terms | "GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0008233 peptidase activity
GO:0016887 ATP hydrolysis activity
GO:0006508 proteolysis
GO:0034605 cellular response to heat
GO:0005737 cytoplasm" |
| Organisms for which functions have been demonstrated | Lacticaseibacillus casei (Lactobacillus casei) |
| Sequence length | 717.0 |
| FASTA sequence | ">tr|A0AAN1EZI8|A0AAN1EZI8_LACCA ATP-dependent Clp protease ATP-binding subunit OS=Lacticaseibacillus casei OX=1582 GN=BGL52_09640 PE=4 SV=1
MANFNDPFFNNHDMDDIFNQMLQGMGKGESARYVVNGHEMTPDEFAQYRATGQLPKQGDE
IPVATTGEQAVKKGGILEKLGRNLTQEAKDGLLDPVIGREHEIQETAEILSRRTKNNPIL
VGDAGVGKTAVVEGLAQAIVKGNVPEAIKDKQIWSIDLSNLEAGTQYRGSFEEKIQNLIK
EVKAAGNVILFFDEIHQILGAGATGGEESGGKGLADIIKPALSRGEITVIGATTQDEYRN
TIMKDSALARRFNDVTINEPSAADTVKILEGVKKLYEQHHHVQLPENVLKAAVDYSIQYI
PQRSLPDKAIDLIDMTAAHLASKHPIVDKVELEKQIKDLNAQKDAAAKAEDFEKAANLKK
EIADKQHQLEGTNDEKPVVATPNDVAAAVERLTGIPVSKLGASDIERLKGIGKRLKGKVI
GQDEAVDMVARAIRRNRAGFDEGNRPIGSFLFVGPTGVGKTELAKQLALDLFGSKDAIIR
LDMSEYSDRTAVSKLIGTSAGYVGYNDNKNTLTEQVRRNPYSIVLLDEIEKADPQVLTLL
LQVLDDGRLTDGQGNVVDFKNTVIIATSNAGFGNEALTGKKEKDGDLMKRLAPYFRPEFL
NRFNGIVEFSHLTKKDLGKIVDLMLEDVNKTLAKKGITLTVTAAAKDWLIAQGYDEAMGA
RPLRRVIERNIRDKVTDFYLDHLKAKKLQADLVDDTIVISEAQPTSGKPKKEAVGAK" |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | _ |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | APTase subunit of the Clp protease involved in degradation of misfolded proteins |
| References for function | _ |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds fibronectin, binds collagen |
| References for function | Munoz-Provencio D, Monedero V. Shotgun phage display of Lactobacillus casei BL23 against collagen and fibronectin. J Microbiol Biotechnol. 2011 Feb;21(2):197-203. doi: 10.4014/jmb.1009.09011. PMID: 21364304. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |