| General Information |
| MoonProt ID | 4112 |
| First appeared in release | 4.0 |
| Name(s) | Glyceraldehyde-3-phosphate dehydrogenase A |
| UniProt ID | P0A9B2 |
| GO terms | "GO:0006096 glycolytic process
GO:0000166 nucleotide binding
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0042802 identical protein binding
GO:0050661 NADP binding
GO:0051287 NAD binding
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
GO:0072524 pyridine-containing compound metabolic process
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane" |
| Organisms for which functions have been demonstrated | Escherichia coli (strain K12) |
| Sequence length | 331.0 |
| FASTA sequence | ">sp|P0A9B2|G3P1_ECOLI Glyceraldehyde-3-phosphate dehydrogenase A OS=Escherichia coli (strain K12) OX=83333 GN=gapA PE=1 SV=2
MTIKVGINGFGRIGRIVFRAAQKRSDIEIVAINDLLDADYMAYMLKYDSTHGRFDGTVEV
KDGHLIVNGKKIRVTAERDPANLKWDEVGVDVVAEATGLFLTDETARKHITAGAKKVVMT
GPSKDNTPMFVKGANFDKYAGQDIVSNASCTTNCLAPLAKVINDNFGIIEGLMTTVHATT
ATQKTVDGPSHKDWRGGRGASQNIIPSSTGAAKAVGKVLPELNGKLTGMAFRVPTPNVSV
VDLTVRLEKAATYEQIKAAVKAAAEGEMKGVLGYTEDDVVSTDFNGEVCTSVFDAKAGIA
LNDNFVKLVSWYDNETGYSNKVLDLIAHISK" |
| Structure Information |
| PDB ID | 1DC3, 1DC4, 1DC5, 1DC6, 1GAD, 1GAE, 1S7C, 2VYN, 2VYV, 5O0V, 5ZA0, 6IO4, 6IO6, 6IOJ, 6UTM, 6UTN, 6UTO, 8JZJ |
| Quaternary structure | homotetramer |
| SCOP | "80008831GAD O:0-330
80008841GAD O:0-330
80688662VYN D:1-333
80688672VYN D:1-333
80983815O0V A:2-331
80983825O0V A:2-331" |
| CATH | "1dc3A01, 1dc3A02, 1dc3B01, 1dc3B02,
1dc4A01, 1dc4A02, 1dc4B01, 1dc4B02,
1dc5A01, 1dc5A02, 1dc5B01, 1dc5B02
1dc6A01, 1dc6A02, 1dc6B01, 1dc6B02
1gadO01, 1gadO02, 1gadP01, 1gadP02
1gaeO01, 1gaeO02, 1gaeP01, 1gaeP02
1s7cA01, 1s7cA02
2vynA01, 2vynA02, 2vynB01, 2vynB02, 2vynC01, 2vynC02, 2vynD01, 2vynD02
2vyvA02, 2vyvB01, 2vyvB02, 2vyvC01, 2vyvC02, 2vyvD01, 2vyvD02, 2vyvA01" |
| TM Helix Prediction | 0 |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, glyceraldehyde 3-phosphate dehydrogenase, catalyzes the reversible oxidative phosphorylation of glyceraldehyde 3-phosphate to 1,3-bisphosphate coupled with reduction of NAD+ to NADH |
| References for function | _ |
| E.C. number | EC:1.2.1.12 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds to EndoIV and UDG in the base-excision repair (BER) pathway for repair of DNA lesions, binds to SSB |
| References for function | Ferreira E, Giménez R, Cañas MA, Aguilera L, Aguilar J, Badia J, Baldomà L. Glyceraldehyde-3-phosphate dehydrogenase is required for efficient repair of cytotoxic DNA lesions in Escherichia coli. Int J Biochem Cell Biol. 2015 Mar;60:202-12. doi: 10.1016/j.biocel.2015.01.008. Epub 2015 Jan 17. PMID: 25603270. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | associated with DNA |
| Comments | |