| General Information |
| MoonProt ID | 416 |
| First appeared in release | 3.0 |
| Name(s) | Anoctamin-6 or Small-conductance calcium-activated nonselective cation channel |
| UniProt ID | Q6P9J9 |
| GO terms | GO:1902476 chloride transmembrane transport
GO:0005254 chloride channel activity
GO:0005886 plasma membrane
GO:0055085 transmembrane transport
GO:0061589 calcium activated phosphatidylserine scrambling
GO:0061590 calcium activated phosphatidylcholine scrambling
GO:0005244 voltage-gated ion channel activity
GO:0005227 calcium activated cation channel activity
GO:0042803 protein homodimerization activity
GO:1902476 chloride transmembrane transport
GO:0017128 phospholipid scramblase activity
GO:0005229 intracellular calcium activated chloride channel activity
GO:0005887 integral component of plasma membrane
GO:0005229 intracellular calcium activated chloride channel activity
GO:0045332 phospholipid translocation
GO:0017121 plasma membrane phospholipid scrambling
GO:0007596 blood coagulation
GO:0030501 positive regulation of bone mineralization
GO:0034767 positive regulation of ion transmembrane transport
GO:0061588 calcium activated phospholipid scrambling
GO:1902476 chloride transmembrane transport
GO:0002407 dendritic cell chemotaxis
GO:0046983 protein dimerization activity
GO:0005244 voltage-gated ion channel activity
GO:0034707 chloride channel complex
GO:0006821 chloride transport
GO:0046872 metal ion binding
GO:0016020 membrane
GO:0005254 chloride channel activity
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0034765 regulation of ion transmembrane transport
GO:0006811 ion transport
GO:0006869 lipid transport
GO:0061591 calcium activated galactosylceramide scrambling
GO:0017128 phospholipid scramblase activity
GO:0006821 chloride transport
GO:0061590 calcium activated phosphatidylcholine scrambling
GO:0061589 calcium activated phosphatidylserine scrambling
GO:0005229 intracellular calcium activated chloride channel activity
GO:1903766 positive regulation of potassium ion export across plasma membrane
GO:1902476 chloride transmembrane transport
GO:0097045 phosphatidylserine exposure on blood platelet
GO:0061588 calcium activated phospholipid scrambling
GO:0061588 calcium activated phospholipid scrambling
GO:0046931 pore complex assembly
GO:0045794 negative regulation of cell volume
GO:0035725 sodium ion transmembrane transport
GO:0035630 bone mineralization involved in bone maturation
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0034767 positive regulation of ion transmembrane transport
GO:0034707 chloride channel complex
GO:0030501 positive regulation of bone mineralization
GO:0017128 phospholipid scramblase activity
GO:0017121 plasma membrane phospholipid scrambling
GO:0006821 chloride transport
GO:0006812 cation transport
GO:0005829 cytosol
GO:0005227 calcium activated cation channel activity
GO:0002543 activation of blood coagulation via clotting cascade
GO:2000353 positive regulation of endothelial cell apoptotic process
GO:0090026 positive regulation of monocyte chemotaxis
GO:0070588 calcium ion transmembrane transport
GO:0042802 identical protein binding
GO:0032060 bleb assembly
GO:0005886 plasma membrane
GO:0005247 voltage-gated chloride channel activity
GO:0005229 intracellular calcium activated chloride channel activity
GO:0002407 dendritic cell chemotaxis
GO:1902476 chloride transmembrane transport
GO:0097045 phosphatidylserine exposure on blood platelet
GO:0046931 pore complex assembly
GO:0045794 negative regulation of cell volume
GO:0035725 sodium ion transmembrane transport
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0034767 positive regulation of ion transmembrane transport
GO:0034707 chloride channel complex
GO:0030501 positive regulation of bone mineralization
GO:0017121 plasma membrane phospholipid scrambling
GO:0006821 chloride transport
GO:0006812 cation transport
GO:0005829 cytosol
GO:0005227 calcium activated cation channel activity
GO:0002543 activation of blood coagulation via clotting cascade
GO:1903766 positive regulation of potassium ion export across plasma membrane
GO:2000353 positive regulation of endothelial cell apoptotic process
GO:0090026 positive regulation of monocyte chemotaxis
GO:0070588 calcium ion transmembrane transport
GO:0032060 bleb assembly
GO:0005886 plasma membrane
GO:0005247 voltage-gated chloride channel activity
GO:1903766 positive regulation of potassium ion export across plasma membrane
GO:0005886 plasma membrane
GO:0030501 positive regulation of bone mineralization
GO:1902476 chloride transmembrane transport
GO:0045794 negative regulation of cell volume
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0034767 positive regulation of ion transmembrane transport
GO:0043065 positive regulation of apoptotic process
GO:0090026 positive regulation of monocyte chemotaxis
GO:0032060 bleb assembly
GO:0070588 calcium ion transmembrane transport
GO:0060100 positive regulation of phagocytosis, engulfment
|
| Organisms for which functions have been demonstrated | Mus musculus (Mouse, mammal) |
| Sequence length | 911 amino acids |
| FASTA sequence | >sp|Q6P9J9|ANO6_MOUSE Anoctamin-6 OS=Mus musculus OX=10090 GN=Ano6 PE=1 SV=1
MQMMTRKVLLNMELEEDDDEDGDIVLENFDQTIVCPTFGSLENQQDFRTPEFEEFNGKPDSLFFTDGQRRIDFILVYEDESKKENNKKGTNEKQKRKRQAYESNLICHGLQLEATRSVSDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKTRSPFGNLNWFTKVLRVNESVIKPEQEFFTAPFEKSRMNDFYILDRDSFFNPATRSRIVYFILSRVKYQVMNNVNKFGINRLVSSGIYKAAFPLHDCRFNYESEDISCPSERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLDQDNCTWSKEVCDPDIGGQILMCPQCDRLCPFWRLNITCESSKKLCIFDSFGTLIFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARPEYEAQCNHVVINEITQEEERIPFTTCGKCIRVTLCASAVFFWILLIIASVIGIIVYRLSVFIVFSTTLPKNPNGTDPIQKYLTPQMATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYLLGKYRSEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWVMNLIGRYKRVSGSEKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRMVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSIPPYGDHTYYTMDGYINNTLSVFNITDFKNTDKENPYIGLGNYTLCRYRDFRNPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHIIYSVKFFISYAIPDVSKITKSKIKREKYLTQKLLHESHLKDLTKNMGIIAERIGGTVDNSVRPKLE |
| Structure Information |
| PDB ID | 6P46_A |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | 8(296-318,371-393,459-481,506-528,556-573,672-694,722-744,826-848) |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | NA |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Ca2+-dependent scrambling of phospholipids |
| References for function | 21107324 |
| E.C. number | NA |
| Location of functional site(s) | NA |
| Cellular location of function | plasma membrane |
| Comments | NA |
| Function 2 |
| Function description | Small-conductance calcium-activated nonselective cation (SCAN) channel |
| References for function | 23021219 |
| E.C. number | NA |
| Location of functional site(s) | NA |
| Cellular location of function | plasma membrane |
| Comments | NA |