| General Information |
| MoonProt ID | 419 |
| First appeared in release | 4.0 |
| Name(s) | GATA1 |
| UniProt ID | P15976 |
| GO terms | "GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001701 in utero embryonic development
GO:0007267 cell-cell signaling
GO:0008285 negative regulation of cell population proliferation
GO:0010725 regulation of primitive erythrocyte differentiation
GO:0030099 myeloid cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030219 megakaryocyte differentiation
GO:0030220 platelet formation
GO:0030502 negative regulation of bone mineralization
GO:0033690 positive regulation of osteoblast proliferation
GO:0035162 embryonic hemopoiesis
GO:0043066 negative regulation of apoptotic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048468 cell development
GO:0048873 homeostasis of number of cells within a tissue
GO:0097028 dendritic cell differentiation
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific" |
| Organisms for which functions have been demonstrated | Homo sapiens (Human) |
| Sequence length | 413.0 |
| FASTA sequence | >sp|P15976|GATA1_HUMAN Erythroid transcription factor OS=Homo sapiens OX=9606 GN=GATA1 PE=1 SV=1 MEFPGLGSLGTSEPLPQFVDPALVSSTPESGVFFPSGPEGLDAAASSTAPSTATAAAAAL AYYRDAEAYRHSPVFQVYPLLNCMEGIPGGSPYAGWAYGKTGLYPASTVCPTREDSPPQA VEDLDGKGSTSFLETLKTERLSPDLLTLGPALPSSLPVPNSAYGGPDFSSTFFSPTGSPL NSAAYSSPKLRGTLPLPPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNRP LIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQVNRPLTMRKD GIQTRNRKASGKGKKKRGSSLGGTGAAEGPAGGFMVVAGGSGSGNCGEVASGLTLGPPGT AHLYQGLGPVVLSGPVSHLMPFPGPLLGSPTGSFPTGPMPPTTSTTVVAPLSS |
| Structure Information |
| PDB ID | 6G0Q |
| Quaternary structure | dimer |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | DNA binding transcription factor |
| References for function | Ugay DA, Batey RT, Wuttke DS. A Distinct Mechanism of RNA Recognition by the Transcription Factor GATA1. Biochemistry. 2025 Mar 18;64(6):1193-1198. doi: 10.1021/acs.biochem.4c00818. Epub 2025 Feb 25. PMID: 39999571; PMCID: PMC11925050. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |
| Function 2 |
| Function description | binds RNA |
| References for function | Ugay DA, Batey RT, Wuttke DS. A Distinct Mechanism of RNA Recognition by the Transcription Factor GATA1. Biochemistry. 2025 Mar 18;64(6):1193-1198. doi: 10.1021/acs.biochem.4c00818. Epub 2025 Feb 25. PMID: 39999571; PMCID: PMC11925050. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |