| General Information |
| MoonProt ID | 427 |
| First appeared in release | 3.0 |
| Name(s) | OCT1, POU2F1, POU domain class 2 transcription factor 1, Octamer-binding protein 1, XOct1, Octamer-binding transcription factor 1, OTF-1, Xloct1-32 |
| UniProt ID | P16143 |
| GO terms | GO:0003700 DNA-binding transcription factor activity
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0005634 nucleus
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organism development
GO:0043565 sequence-specific DNA binding
GO:0005737 cytoplasm
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0042981 regulation of apoptotic process
GO:0005667 transcription regulator complex
GO:0060019 radial glial cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0007219 Notch signaling pathway |
| Organisms for which functions have been demonstrated | Xenopus laevis (African clawed frog) |
| Sequence length | 758 amino acids |
| FASTA sequence | >sp|P16143|PO2F1_XENLA POU domain, class 2, transcription factor 1 OS=Xenopus laevis OX=8355 GN=pou2f1 PE=1 SV=3
MKLHSSSKIQNHAWLSDARMNNPSETSKSPESGDGNTGTQTNGLDFQKQAVPIGAITSAQAQALLGHLHQVQLAGTSLQAAAHSLNVQTKFKEEPGEPMQVVQPSQQPSLQAAIPQTQLMVAGGQIAGLTLTPAQQQMLLQQAQAQLLAAAVQHSASQQHNAAGATISASAATPMTQIPLSQPIQIAQDLQQLQQLQQQNLNLQQYVLVHPTTNLQSAQFIISQTPQGQQGLLQAQNLLTQLPQQSQANLLQSQPSITLTSQPATPTRTIAATPVQQLPQSQTTPKRIDTPSLEEPSDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAENITSDSTLTNQSVLNSPGHGMEGLNRRRKKRTSIETNIRVALEKSFLENQKPTSEEITMIADQLNMEKEVIRVWFCNRRQKEKRINPPSSGGSSSSPIKSLFSSPNPLVASTPSLVTSSPATTLTVNPVLPLTSAAAITSFHIPGTTGTSSANTATVISTAPPVSSVLTSPSLSSSPSATAASSEASTAGETSTTQTTSTPMTSSLNTGQVMVTASGIHTAAATALQGAAQLPTNASLAAMAAAAGLNPGLMAPSQFAAGGALFSLNPGALGSALSPALMSNSTLATIQALASSGSLPITSLDAAGNLVFANAGGTPNIVTAPLFLNPQNLSLFTSNPVSLISAASAGATGPITSLHATTSSIDSIQNALFTMASASGAASTTTSASKAQ |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | Use FASTA sequence on the MFDp2 webserver.
moonID_427_uniID_P16143 is 758 residues long, with 313 residues (41.29%) predicted as disordered.The protein has 2 short (< 30 residues) disorder segments and 3 long (>= 30 residues) disorder segments.
Segment 1 - Long (>= 30 residues) disordered segment Segment is located between positions 1 and 50 in the sequence. The segment is 50 residues long (6.60 % of the total sequence length).
Segment 2 - Long (>= 30 residues) disordered segment Segment is located between positions 231 and 305 in the sequence. The segment is 75 residues long (9.89 % of the total sequence length).
Segment 3 - Short (< 30 residues) disordered segment Segment is located between positions 376 and 403 in the sequence. The segment is 28 residues long (3.69 % of the total sequence length).
Segment 4 - Long (>= 30 residues) disordered segment Segment is located between positions 451 and 598 in the sequence. The segment is 148 residues long (19.53 % of the total sequence length).
Segment 5 - Short (< 30 residues) disordered segment Segment is located between positions 747 and 758 in the sequence. The segment is 12 residues long (1.58 % of the total sequence length). |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Transcription factor that binds to an octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and histone H2B. |
| References for function | 1406629 |
| E.C. number | NA |
| Location of functional site(s) | NA |
| Cellular location of function | nucleus |
| Comments | NA |
| Function 2 |
| Function description | Interacts with BRCA1, binds PARP-1 and APC1 |
| References for function | 21897860 |
| E.C. number | NA |
| Location of functional site(s) | NA |
| Cellular location of function | Centrosomes, kinetochores, and midbody DZ |
| Comments | Morphologically abnormal spindles in Oct1-immunodepleted Xenopus egg extracts |