General Information |
MoonProt ID | 428 |
First appeared in release | 3.0 |
Name(s) | Anoctamin |
UniProt ID | Q9VDV4 ( |
GO terms | GO:0046983 protein dimerization activity
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0005247 voltage-gated chloride channel activity
GO:0097603 temperature-gated ion channel activity
GO:0005229 intracellular calcium activated chloride channel activity
GO:0006821 chloride transport
GO:0050829 defense response to Gram-negative bacterium
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0016020 membrane
GO:0034220 ion transmembrane transport
GO:1902476 chloride transmembrane transport
|
Organisms for which functions have been demonstrated | Drosophila melanogaster (fruit fly, an insect) |
Sequence length | 1075 amino acids |
FASTA sequence | >tr|Q9VDV4|Q9VDV4_DROME Anoctamin OS=Drosophila melanogaster OX=7227 GN=subdued PE=2 SV=1
MLNLGSAKVGALEEATSPPPFSKDESFQLLERSPHNPAISPTTTVPLEPPFTTPLAPFMELMKRHNLHERLTGKESFWRGRDTSQRFLDQEQLSASRESLGAADKRARFAESNAPTLQLPESAEPRANGKRPTGNRTNPSNPAAPLLPMTDPDFVKGNVGGVYDDRECSCPREFYQRGEINTSLFFEDCVRSIDFVLAYRINAHEPTELENTEKRRVFEANLISQGLEVESSQKDQIWFVKIHAPLEVLRRYAEILKLRMPMKEIPGMSVVNRSTKSVFSSLKHVFQFFLRNIYVDEEIFPKRAHRFTAIYSRDKEYLFDIRQDCFFTTAVRSRIVEFILDRQRFPAKNQHDMAFGIERLIAEGVYSAAYPLHDGEITETGTMRALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDICQSGNTNITMCPLCDWCNFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHRWDLTGFDVHEEHPRPQYLARLEHIPPTRVDYVTNIKEPTVPFWRMKLPATVFSFSVVLLLIALAFVALLAVVVYRMSMLAALKVGASPMTTSSAIVLATASAAFVNLCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLFDYRQEECSSGGCLTELCIQLAIIMVGKQAFNTILEVYLPMFWRKVLAIQVGLSRLFNNTPNPDKAKDERWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYRHYVNKQGTLDGYLNFTLSEFKVIDSPTLYSLAGDLSNITTCRYTDFRLPPSSPEKYTLSSMFYIILACRLGFVVVFENFVALVMILVRWCIPDMSVELRDQIRREVYVTNEIIIDQEAHRARFERAKRSSSVLQTPVDQDMDAASIQEPNAKFINIEKLLTENLTQIEMDAIIHGENPITGISGADCLDEVHKKLSD |
Structure Information |
PDB ID | NA |
Quaternary structure | NA |
SCOP | NA |
CATH | NA |
TM Helix Prediction | 6(422-444, 574-596, 616-638, 662-684, 792-814, 942-964) |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | Use FASTA sequence on the MFDp2 webserver.
moonID_428_uniID_Q9VDV4 is 1075 residues long, with 222 residues (20.65%) predicted as disordered.The protein has 0 short (< 30 residues) disorder segments and 2 long (>= 30 residues) disorder segments.
Segment 1 - Long (>= 30 residues) disordered segment Segment is located between positions 1 and 180 in the sequence. The segment is 180 residues long (16.74 % of the total sequence length).
Segment 2 - Long (>= 30 residues) disordered segment Segment is located between positions 994 and 1035 in the sequence. The segment is 42 residues long (3.91 % of the total sequence length). |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | Calcium activated chloride channel |
References for function | 24192034 |
E.C. number | NA |
Location of functional site(s) | NA |
Cellular location of function | Plama membrane |
Comments | NA |
Function 2 |
Function description | CaPLSase, Upon Ca2 binding, TMEM16F–CaPLSase mediates the rapid flip-flopping of phospholipids across cell membranes and thus dissipates the asymmetric distribution of membrane phospholipids. During platelet activation, TMEM16F–CaPLSase–induced phosphatidylserine (PS) externalization is essential for prothrombinase assembly, subsequent thrombin generation, and blood coagulation |
References for function | 30700552 |
E.C. number | NA |
Location of functional site(s) | NA |
Cellular location of function | plasma membrane |
Comments | NA |