Protein Information

General Information
MoonProt ID428
First appeared in release3.0
Name(s)Anoctamin
UniProt IDQ9VDV4 (
GO termsGO:0046983 protein dimerization activity GO:0016020 membrane GO:0016021 integral component of membrane GO:0005247 voltage-gated chloride channel activity GO:0097603 temperature-gated ion channel activity GO:0005229 intracellular calcium activated chloride channel activity GO:0006821 chloride transport GO:0050829 defense response to Gram-negative bacterium GO:0050965 detection of temperature stimulus involved in sensory perception of pain GO:0016020 membrane GO:0034220 ion transmembrane transport GO:1902476 chloride transmembrane transport
Organisms for which functions have been demonstratedDrosophila melanogaster (fruit fly, an insect)
Sequence length1075 amino acids
FASTA sequence>tr|Q9VDV4|Q9VDV4_DROME Anoctamin OS=Drosophila melanogaster OX=7227 GN=subdued PE=2 SV=1 MLNLGSAKVGALEEATSPPPFSKDESFQLLERSPHNPAISPTTTVPLEPPFTTPLAPFMELMKRHNLHERLTGKESFWRGRDTSQRFLDQEQLSASRESLGAADKRARFAESNAPTLQLPESAEPRANGKRPTGNRTNPSNPAAPLLPMTDPDFVKGNVGGVYDDRECSCPREFYQRGEINTSLFFEDCVRSIDFVLAYRINAHEPTELENTEKRRVFEANLISQGLEVESSQKDQIWFVKIHAPLEVLRRYAEILKLRMPMKEIPGMSVVNRSTKSVFSSLKHVFQFFLRNIYVDEEIFPKRAHRFTAIYSRDKEYLFDIRQDCFFTTAVRSRIVEFILDRQRFPAKNQHDMAFGIERLIAEGVYSAAYPLHDGEITETGTMRALLYKHWASVPKWYRYQPLDDIKEYFGVKIGLYFAWLGYYTYMLLLASIVGVICFLYSWFSLKNYVPVKDICQSGNTNITMCPLCDWCNFWDLKETCNYAKVTYLIDNPSTVFFAVFMSFWATLFLELWKRYSAEITHRWDLTGFDVHEEHPRPQYLARLEHIPPTRVDYVTNIKEPTVPFWRMKLPATVFSFSVVLLLIALAFVALLAVVVYRMSMLAALKVGASPMTTSSAIVLATASAAFVNLCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSLTLKIYLLQFVNYYASIFYIAFFKGKFVGHPGEYNKLFDYRQEECSSGGCLTELCIQLAIIMVGKQAFNTILEVYLPMFWRKVLAIQVGLSRLFNNTPNPDKAKDERWMRDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMRLDAKKLLTHHKRPVSQRVRDIGVWYRILDCIGKLSVITNGFIIAFTSDMIPRLVYRHYVNKQGTLDGYLNFTLSEFKVIDSPTLYSLAGDLSNITTCRYTDFRLPPSSPEKYTLSSMFYIILACRLGFVVVFENFVALVMILVRWCIPDMSVELRDQIRREVYVTNEIIIDQEAHRARFERAKRSSSVLQTPVDQDMDAASIQEPNAKFINIEKLLTENLTQIEMDAIIHGENPITGISGADCLDEVHKKLSD
Structure Information
PDB IDNA
Quaternary structureNA
SCOPNA
CATHNA
TM Helix Prediction6(422-444, 574-596, 616-638, 662-684, 792-814, 942-964)
DisProt AnnotationNot in DisProt
Predicted Disorder RegionsUse FASTA sequence on the MFDp2 webserver. moonID_428_uniID_Q9VDV4 is 1075 residues long, with 222 residues (20.65%) predicted as disordered.The protein has 0 short (< 30 residues) disorder segments and 2 long (>= 30 residues) disorder segments. Segment 1 - Long (>= 30 residues) disordered segment Segment is located between positions 1 and 180 in the sequence. The segment is 180 residues long (16.74 % of the total sequence length). Segment 2 - Long (>= 30 residues) disordered segment Segment is located between positions 994 and 1035 in the sequence. The segment is 42 residues long (3.91 % of the total sequence length).
Connections to Disease
OMIM ID
Function 1
Function descriptionCalcium activated chloride channel
References for function24192034
E.C. numberNA
Location of functional site(s)NA
Cellular location of functionPlama membrane
CommentsNA
Function 2
Function descriptionCaPLSase, Upon Ca2 binding, TMEM16F–CaPLSase mediates the rapid flip-flopping of phospholipids across cell membranes and thus dissipates the asymmetric distribution of membrane phospholipids. During platelet activation, TMEM16F–CaPLSase–induced phosphatidylserine (PS) externalization is essential for prothrombinase assembly, subsequent thrombin generation, and blood coagulation
References for function30700552
E.C. numberNA
Location of functional site(s)NA
Cellular location of functionplasma membrane
CommentsNA