General Information |
MoonProt ID | 43 |
First appeared in release | 1.0 |
Name(s) | enolase
Gene Name: ENO |
UniProt ID | Q3HL75 (Q3HL75_LEIME), Unreviewed |
GO terms | GO:0006096 glycolysis
GO:0000287 magnesium ion binding
GO:0004634 phosphopyruvate hydratase activity
GO:0016829 lyase activity
GO:0000015 phosphopyruvate hydratase complex |
Organisms for which functions have been demonstrated | Leishmania mexicana (causes human leishmaniasis) |
Sequence length | 429 |
FASTA sequence | >gi|77176833|gb|ABA64522.1| enolase [Leishmania mexicana]
MPILKIHAREVLDSRGNPTVEVELTTEAGVFRSAVPSGASTGVHEACELRDGDKARYCGAGCTQAVKYVNEILAPALVGKDESDQAGLDKLMCELDGTKNKSKLGANAILGCSMAISKAAAAKAGVPLYRYIAGLAGTKDMRLPVPCFNVINGGKHAGNVLPFQEFMIAPTKATSFREALRMGSEVYHALKGIIKGKYGQDAVNVGDEGGFAPPIKQIDEPLPILMEAIEKAGHKGKFAICMDCAASEAYDAERKMYNLTFKNPEPTYVSAAKLQETYERWVSEYPLVSIEDPFAEDNFDEFSAITKALAGKAQIVGDDLTVTNVERVKMAIDKSACNSLLLKINQIGTISESIAAAKLCMENGWSVMVSHRSGETEDTYIADLSVGLGTGQIKTGAPCRGERTAKLNQLLRIEEEMGSAAKYGYPGWA |
Structure Information |
PDB ID | closest is Trypanosoma at 74% amino acid sequence identity |
Quaternary structure | |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1-3,429-434 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | enolase, enzyme
reversible conversion of 2-phosphoglycerate to phosphoenolpyruvate |
References for function | |
E.C. number | 4.2.1.11 |
Location of functional site(s) | |
Cellular location of function | cytosol |
Comments | |
Function 2 |
Function description | binds plasminogen |
References for function | Vanegas G, Qui?ones W, CarrascoL?pez C, Concepci?n JL, Albericio F, Avil?n L. Enolase as a plasminogen binding protein in Leishmania mexicana. Parasitol Res. 2007 Nov;101(6):1511-6. Epub 2007 Jul 27.
PMID: 17653767 |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | cell surface |
Comments | |