| General Information |
| MoonProt ID | 433 |
| First appeared in release | 3.0 |
| Name(s) | Thioredoxin peroxidase |
| UniProt ID | P91883 |
| GO terms | GO:0055114 oxidation-reduction process
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0051920 peroxiredoxin activity
GO:0004601 peroxidase activity
GO:0098869 cellular oxidant detoxification |
| Organisms for which functions have been demonstrated | Fasciola hepatica |
| Sequence length | 194 amino acids |
| FASTA sequence | >sp|P91883|TDX_FASHE Thioredoxin peroxidase OS=Fasciola hepatica OX=6192 PE=2 SV=1 MLQPNMPAPNFSGQAVVGKEFETISLSDYKGKWVILAFYPLDFTFVCPTEIIAISDQMEQFAQRNCAVIFCSTDSVYSHLQWTKMDRKVGGIGQLNFPLLADKNMSVSRAFGVLDEEQGNTYRGNFLIDPKGVLRQITVNDDPVGRSVEEALRLLDAFIFHEEHGEVCPANWKPKSKTIVPTPDGSKAYFSSAN |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | monomer |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | Use FASTA sequence on the MFDp2 webserver.
moonID_433_uniID_P91883 is 194 residues long, with 14 residues (7.22%) predicted as disordered.The protein has 1 short (< 30 residues) disorder segment and 0 long (>= 30 residues) disorder segments.
Segment 1 - Short (< 30 residues) disordered segment Segment is located between positions 181 and 194 in the sequence. The segment is 14 residues long (7.22 % of the total sequence length). |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Thioredoxin peroxidase, protection against ROS, antioxidant, oxidoreductase |
| References for function | 15618151 |
| E.C. number | 1.11.1.24 |
| Location of functional site(s) | NA |
| Cellular location of function | cytoplasm |
| Comments | NA |
| Function 2 |
| Function description | cytokine, Regulates alternative activation of macrophages, inducing Th2 response |
| References for function | 15618151 |
| E.C. number | NA |
| Location of functional site(s) | NA |
| Cellular location of function | Extracellular (secreted) |
| Comments | NA |