| General Information |
| MoonProt ID | 44 |
| First appeared in release | 1.0 |
| Name(s) | enolase
2-phospho-D-glycerate hydrolase |
| UniProt ID | A5JQI1 (A5JQI1_PARBR), Unreviewed |
| GO terms | GO:0006096 glycolysis
GO:0000287 magnesium ion binding
GO:0004634 phosphopyruvate hydratase activity
GO:0016829 lyase activity
GO:0000015 phosphopyruvate hydratase complex |
| Organisms for which functions have been demonstrated | Paracoccidioides brasiliensis |
| Sequence length | 438 |
| FASTA sequence | >gi|146762537|gb|ABQ45367.1| enolase [Paracoccidioides brasiliensis]
MAITKIHARSVYDSRGNPTVEVDVVTETGLHRAIVPSGASTGQHEACELRDGDQSKWLGKGVLNAVKNVNSVIGPAIIKENIDVKDQSKVDEFLNKLDGTPNKSKLGANAILGVSLAIAKAGAAEKGVPLYAHVSDLAGTKKPYVLPVPFQNVLNGGSHAGGRLAFQEFMIVPTAAPSFSEALRQGSEVYHKLKALAKKKYGQSAGNVGDEGGVAPDIQTPEEALDLITEAIEQAGYTGQVKIALDIASSEFYKADEKKYDLDFKNPDSDKSKWLTYEQLADLYKKLASKYAIVSIEDPFAEDDWEAWSYYFKTCDLQVVADDLTVTNPIRIKKAIELKSCNALLLKVNQIGTLTESIQAAKDSYAAGWGVMVSHRSGETEDVTIADIVVGLRAGQIKTGAPARSERLAKLNQILRIEEELGSNAVYAGDKFRAAINM |
| Structure Information |
| PDB ID | closest is 75% amino acid sequence identity |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-4,434-438 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enolase, enzyme
catalyses the dehydration of 2-phospho-D-glycerate (PGA) to phosphoenolpyruvate
glycolysis, gluconeogenesis |
| References for function | |
| E.C. number | 4.2.1.11 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | fibronectin binding |
| References for function | Donofrio FC, Calil AC, Miranda ET, Almeida AM, Benard G, Soares CP, Veloso SN, Soares CM, Mendes Giannini. Enolase from Paracoccidioides brasiliensis: isolation and identification as a fibronectin-binding protein.J Med Microbiol. 2009 Jun;58(Pt 6):706-13. doi: 10.1099/jmm.0.003830-0.
PMID: 19429745 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |