Protein Information

General Information
MoonProt ID451
First appeared in release3.0
Name(s)Stromelysin-1, Matrix metalloproteinase-3, Transin-1 Gene: MMP3
UniProt IDP03957 (MMP3_RAT)
GO termsGO:0001666 response to hypoxia GO:0004175 endopeptidase activity GO:0004222 metalloendopeptidase activity GO:0005576 extracellular region GO:0005615 extracellular space GO:0005634 nucleus GO:0005739 mitochondrion GO:0005829 cytosol GO:0006508 proteolysis GO:0007565 female pregnancy GO:0008233 peptidase activity GO:0008237 metallopeptidase activity GO:0008270 zinc ion binding GO:0009612 response to mechanical stimulus GO:0010727 negative regulation of hydrogen peroxide metabolic process GO:0016787 hydrolase activity GO:0030163 protein catabolic process GO:0030198 extracellular matrix organization GO:0030334 regulation of cell migration GO:0030335 positive regulation of cell migration GO:0030425 dendrite GO:0030574 collagen catabolic process GO:0031012 extracellular matrix GO:0031334 positive regulation of protein-containing complex assembly GO:0032355 response to estradiol GO:0032496 response to lipopolysaccharide GO:0032991 protein-containing complex GO:0034097 response to cytokine GO:0034612 response to tumor necrosis factor
Organisms for which functions have been demonstratedRattus norvegicus (Rat, mammal)
Sequence length475 amino acids
FASTA sequence>sp|P03957|MMP3_RAT Stromelysin-1 OS=Rattus norvegicus OX=10116 GN=Mmp3 PE=1 SV=1 MKGLPVLLWLCTAVCSSYPLHGSEEDAGMEVLQKYLENYYGLEKDVKQFTKKKDSSPVVKKIQEMQKFLGLKMTGKLDSNTMELMHKPRCGVPDVGGFSTFPGSPKWRKNHISYRIVNYTLDLPRESVDSAIERALKVWEEVTPLTFSRISEGEADIMISFAVEEHGDFIPFDGPGMVLAHAYAPGPGTNGDAHFDDDERWTDDVTGTNLFLVAAHELGHSLGLFHSANAEALMYPVYKSSTDLARFHLSQDDVDGIQSLYGPPTESPDVLVVPTKSNSLDPETLPMCSSALSFDAVSTLRGEVLFFKDRHFWRKSLRTPEPGFYLISSFWPSLPSNMDAAYEVTNRDTVFILKGNQIWAIRGHEELAGYPKSIHTLGLPETVQKIDAAISLKDQKKTYFFVEDKFWRFDEKKQSMDPEFPRKIAENFPGIGTKVDAVFEAFGFLYFFSGSSQLEFDPNAGKVTHILKSNSWFNC
Structure Information
PDB IDNA
Quaternary structureNA
SCOPNA
CATHNA
TM Helix Predictionno TM helices
DisProt AnnotationNot in DisProt
Predicted Disorder RegionsUse FASTA sequence on the MFDp2 webserver. moonID_451_uniID_P03957 is 475 residues long, with 0 residues (0.00%) predicted as disordered.The protein has 0 short (< 30 residues) disorder segments and 0 long (>= 30 residues) disorder segments.
Connections to Disease
OMIM ID
Function 1
Function descriptionMetalloprotease (degrades fibronectin, gelatin, proteoglycans, denatured type I collagen, laminin, and other extracellular matrix components)
References for functionUmenishi F, Yasumitsu H, Ashida Y, Yamauti J, Umeda M, Miyazaki K. Purification and properties of extracellular matrix-degrading metallo-proteinase overproduced by Rous sarcoma virus-transformed rat liver cell line, and its identification as transin. J Biochem. 1990;108(4):537-543. doi:10.1093/oxfordjournals.jbchem.a123238
E.C. number3.4.24.17
Location of functional site(s)NA
Cellular location of functioncell surface
CommentsNA
Function 2
Function descriptiontranscription factor
References for functionNA
E.C. numberNA
Location of functional site(s)NA
Cellular location of functionnucleus
CommentsNA