Protein Information

General Information
MoonProt ID458
First appeared in release3.0
Name(s)EF-Tu Elongation factor Tu
UniProt IDQ8G5B7 (EFTU_BIFLO)
GO termsGO:0005525 GTP binding GO:0006412 translation GO:0003746 translation elongation factor activity GO:0006414 translational elongation GO:0005737 cytoplasm GO:0000166 nucleotide binding
Organisms for which functions have been demonstratedBifidobacterium longum (strain NCC 2705) (Gram positive bacterium)
Sequence length399 amino acids
FASTA sequence>sp|Q8G5B7|EFTU_BIFLO Elongation factor Tu OS=Bifidobacterium longum (strain NCC 2705) OX=206672 GN=tuf PE=3 SV=1 MAKEKYERTKPHVNIGTIGHVDHGKTTLTAAISKVLHEEFPDVNPEYDFNQIDSAPEEAARGITINIAHIEYQTEKRHYAHVDCPGHADFVKNMITGAAQMDGAILVVAATDGPMAQTREHVLLARQVGVPKILVALNKCDMVDDEELIELVEEEVRDLLDENGFDRDCPVIHTSAYGALHDDAPDHEKWVQSVKDLMDAVDDYIPTPVHDLDKPFLMPIEDVFTISGRGTVVTGRVERGQLAVNTPVEIVGIRPTQQTTVTSIETFHKTMDACEAGDNTGLLLRGLGRDDVERGQVVAKPGSVTPHTKFEGEVYVLTKDEGGRHSPFFSNYRPQFYFRTTDVTGVIELPEGVEMVQPGDHATFTVELIQPIAMEEGLTFAVREGGHTVGSGRVTKILA
Structure Information
PDB IDNA
Quaternary structureNA
SCOP
CATH
TM Helix Predictionno TM helices # sp|Q8G5B7|EFTU_BIFLO Number of predicted TMHs: 0 # sp|Q8G5B7|EFTU_BIFLO Exp number of AAs in TMHs: 0.04281 # sp|Q8G5B7|EFTU_BIFLO Exp number, first 60 AAs: 0.00183 # sp|Q8G5B7|EFTU_BIFLO Total prob of N-in: 0.08519 sp|Q8G5B7|EFTU_BIFLO TMHMM2.0 outside 1 399
DisProt AnnotationNot in DisProt
Predicted Disorder RegionsUse FASTA sequence on MFDp2 webserver. spQ8G5B7EFTU_BIFLO_Elong is 399 residues long, with 17 residues (4.26 %) predicted as disordered. The protein has 1 short (< 30 residues) disorder segment and 0 long (>= 30 residues) disorder segments. Segment 1 - Short (< 30 residues) disordered segment Segment is located between positions 1 and 17 in the sequence. The segment is 17 residues long (4.26 % of the total sequence length).
Connections to Disease
OMIM ID
Function 1
Function descriptionelognation factor
References for functionVentura M, Canchaya C, Meylan V, Klaenhammer TR, Zink R. Analysis, characterization, and loci of the tuf genes in lactobacillus and bifidobacterium species and their direct application for species identification. Appl Environ Microbiol. 2003 Nov;69(11):6908-22. doi: 10.1128/aem.69.11.6908-6922.2003. PMID: 14602655; PMCID: PMC262312.
E.C. number
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionbinds mucin
References for functionNishiyama K, Takaki T, Sugiyama M, Fukuda I, Aiso M, Mukai T, Odamaki T, Xiao JZ, Osawa R, Okada N. Extracellular vesicles produced by Bifidobacterium longum export mucin-binding proteins. Appl Environ Microbiol. 2020 Jul 31:AEM.01464-20. doi: 10.1128/AEM.01464-20. Epub ahead of print. PMID: 32737132.
E.C. number
Location of functional site(s)
Cellular location of functionextracellular
Comments