Protein Information

General Information
MoonProt ID465
First appeared in release3.0
Name(s)KIF3A. Kinesin-like protein KIF3A. Recommended name: Kinesin-like protein KIF3A; Alternative name(s): Microtubule plus end-directed kinesin motor 3A.
UniProt IDP28741 (KIF3A_MOUSE)
GO termsGO:0005515 centriole GO:0005515 cilium GO:2000771 photoreceptor connecting cilium GO:1905128 microtubule anchoring at centrosome GO:0097470 centriole-centriole cohesion GO:0090316 cilium assembly GO:0048260 protein binding GO:0005930 cell projection GO:1904115 cell projection organization GO:0044877 microtubule GO:0043025 cytoskeleton GO:0019894 ATP binding GO:0021904 cytoplasm GO:0060271 nucleotide binding
Organisms for which functions have been demonstratedMus musculus (Mouse, mammal)
Sequence length701 amino acids
FASTA sequence>sp|P28741|KIF3A_MOUSE Kinesin-like protein KIF3A OS=Mus musculus OX=10090 GN=Kif3a PE=1 SV=2 MPINKSEKPESCDNVKVVVRCRPLNEREKSMCYRQAVSVDEMRGTITVHKTDSSNEPPKTFTFDTVFGPESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGLRGVIPNSFAHIFGHIAKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNMHVRMGKLHLVDLAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEVSGSDISGSEEDDEEGELGEDGEKKKKRRDQAGKKKVSPDKMVEMQAKIDEERKALETKLDMEEEERNKARAELERREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLEESNMELEERRRRAEQLRKELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPQDYQEMIENYVHWNEDIGEWQLKCVAYTGNNMRKQTPVPDKKERDPFEVDLSHVYLAYTEESLRQSLMKLERPRTSKGKARPKMGRRKRSAKPETVIDSLLQ
Structure Information
PDB ID5JVR, 5JX1
Quaternary structureNA
SCOPclass 1000000 All alpha proteins; fold 2000835 EB1 dimerisation domain-like; superfamily 3001381 EB1 dimerisation domain-like; family 4001361 RP/EB dimerisation domain-like; domain 8018824 this domain is represented by 1WU9 A:191-249 Microtubule-associated protein RP/EB family member 1. Species Homo sapiens.
CATH1 matching superfamily. Superfamily: 1.20.5.1430 CATH superfamily 1.20.5.1430. 3 mathcing domains. Domain: 5jvrA00 PDB code 5jvr, chain A, domain 00 Superfamily: 1.20.5.1430 Domain: 5jvrF00 PDB code 5jvr, chain F, domain 00 Superfamily: 1.20.5.1430 Domain: 5jvrH00 PDB code 5jvr, chain H, domain 00 Superfamily: 1.20.5.1430
TM Helix Predictionno TM helices # sp|P28741|KIF3A_MOUSE Number of predicted TMHs: 0 # sp|P28741|KIF3A_MOUSE Exp number of AAs in TMHs: 0.01324 # sp|P28741|KIF3A_MOUSE Exp number, first 60 AAs: 0 # sp|P28741|KIF3A_MOUSE Total prob of N-in: 0.00082 sp|P28741|KIF3A_MOUSE TMHMM2.0 outside 1 701
DisProt Annotation
Predicted Disorder RegionsUse FASTA sequence on MFDp2 webserver. spP28741KIF3A_MOUSE_Kine is 701 residues long, with 284 residues (40.51 %) predicted as disordered. The protein has 1 short (< 30 residues) disorder segment and 2 long (>= 30 residues) disorder segments. Segment 1 - Short (< 30 residues) disordered segment Segment is located between positions 1 and 19 in the sequence. The segment is 19 residues long (2.71 % of the total sequence length). Segment 2 - Long (>= 30 residues) disordered segment Segment is located between positions 351 and 536 in the sequence. The segment is 186 residues long (26.53 % of the total sequence length). Segment 3 - Long (>= 30 residues) disordered segment Segment is located between positions 623 and 701 in the sequence. The segment is 79 residues long (11.27 % of the total sequence length).
Connections to Disease
OMIM ID
Function 1
Function descriptionMouse ciliary protein.
References for functionChoi YH, Suzuki A, Hajarnis S, Ma Z, Chapin HC, Caplan MJ, Pontoglio M, Somlo S, Igarashi P. Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10679-84. doi: 10.1073/pnas.1016214108. Epub 2011 Jun 13. PMID: 21670265; PMCID: PMC3127890.
E.C. number
Location of functional site(s)
Cellular location of functioncilium
Comments
Function 2
Function descriptionregulates NFkappaB signaling
References for functionMcFie M, Koneva L, Collins I, Coveney CR, Clube AM, Chanalaris A, Vincent TL, Bezbradica JS, Sansom SN, Wann AK. Ciliary proteins specify the cell inflammatory response by tuning NFkB signaling, independently of primary cilia. Journal of Cell Science. 2020 Jan 1. PMID: 32503942
E.C. number
Location of functional site(s)
Cellular location of functioncytoplasm
Comments