General Information |
MoonProt ID | 465 |
First appeared in release | 3.0 |
Name(s) | KIF3A.
Kinesin-like protein KIF3A.
Recommended name:
Kinesin-like protein KIF3A;
Alternative name(s):
Microtubule plus end-directed kinesin motor 3A. |
UniProt ID | P28741 (KIF3A_MOUSE) |
GO terms | GO:0005515 centriole
GO:0005515 cilium
GO:2000771 photoreceptor connecting cilium
GO:1905128 microtubule anchoring at centrosome
GO:0097470 centriole-centriole cohesion
GO:0090316 cilium assembly
GO:0048260 protein binding
GO:0005930 cell projection
GO:1904115 cell projection organization
GO:0044877 microtubule
GO:0043025 cytoskeleton
GO:0019894 ATP binding
GO:0021904 cytoplasm
GO:0060271 nucleotide binding |
Organisms for which functions have been demonstrated | Mus musculus (Mouse, mammal) |
Sequence length | 701 amino acids |
FASTA sequence | >sp|P28741|KIF3A_MOUSE Kinesin-like protein KIF3A OS=Mus musculus OX=10090 GN=Kif3a PE=1 SV=2
MPINKSEKPESCDNVKVVVRCRPLNEREKSMCYRQAVSVDEMRGTITVHKTDSSNEPPKTFTFDTVFGPESKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPGLRGVIPNSFAHIFGHIAKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQTQRLEVKERPDVGVYIKDLSAYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNMHVRMGKLHLVDLAGSERQAKTGATGQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGNSKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINEDPKDALLRQFQKEIEELKKKLEEGEEVSGSDISGSEEDDEEGELGEDGEKKKKRRDQAGKKKVSPDKMVEMQAKIDEERKALETKLDMEEEERNKARAELERREKDLLKAQQEHQSLLEKLSALEKKVIVGGVDLLAKAEEQEKLLEESNMELEERRRRAEQLRKELEEKEQERLDIEEKYTSLQEEAQGKTKKLKKVWTMLMAAKSEMADLQQEHQREIEGLLENIRQLSRELRLQMLIIDNFIPQDYQEMIENYVHWNEDIGEWQLKCVAYTGNNMRKQTPVPDKKERDPFEVDLSHVYLAYTEESLRQSLMKLERPRTSKGKARPKMGRRKRSAKPETVIDSLLQ |
Structure Information |
PDB ID | 5JVR, 5JX1 |
Quaternary structure | NA |
SCOP | class 1000000 All alpha proteins;
fold 2000835 EB1 dimerisation domain-like;
superfamily 3001381 EB1 dimerisation domain-like;
family 4001361 RP/EB dimerisation domain-like;
domain 8018824 this domain is represented by 1WU9 A:191-249 Microtubule-associated protein RP/EB family member 1. Species Homo sapiens. |
CATH | 1 matching superfamily.
Superfamily: 1.20.5.1430 CATH superfamily 1.20.5.1430.
3 mathcing domains. Domain: 5jvrA00 PDB code 5jvr, chain A, domain 00 Superfamily: 1.20.5.1430
Domain: 5jvrF00 PDB code 5jvr, chain F, domain 00 Superfamily: 1.20.5.1430
Domain: 5jvrH00 PDB code 5jvr, chain H, domain 00 Superfamily: 1.20.5.1430 |
TM Helix Prediction | no TM helices
# sp|P28741|KIF3A_MOUSE Number of predicted TMHs: 0
# sp|P28741|KIF3A_MOUSE Exp number of AAs in TMHs: 0.01324
# sp|P28741|KIF3A_MOUSE Exp number, first 60 AAs: 0
# sp|P28741|KIF3A_MOUSE Total prob of N-in: 0.00082
sp|P28741|KIF3A_MOUSE TMHMM2.0 outside 1 701 |
DisProt Annotation | |
Predicted Disorder Regions | Use FASTA sequence on MFDp2 webserver.
spP28741KIF3A_MOUSE_Kine is 701 residues long, with 284 residues (40.51 %) predicted as disordered. The protein has 1 short (< 30 residues) disorder segment and 2 long (>= 30 residues) disorder segments.
Segment 1 - Short (< 30 residues) disordered segment
Segment is located between positions 1 and 19 in the sequence.
The segment is 19 residues long (2.71 % of the total sequence length).
Segment 2 - Long (>= 30 residues) disordered segment
Segment is located between positions 351 and 536 in the sequence.
The segment is 186 residues long (26.53 % of the total sequence length).
Segment 3 - Long (>= 30 residues) disordered segment
Segment is located between positions 623 and 701 in the sequence.
The segment is 79 residues long (11.27 % of the total sequence length). |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | Mouse ciliary protein. |
References for function | Choi YH, Suzuki A, Hajarnis S, Ma Z, Chapin HC, Caplan MJ, Pontoglio M, Somlo S, Igarashi P. Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10679-84. doi: 10.1073/pnas.1016214108. Epub 2011 Jun 13. PMID: 21670265; PMCID: PMC3127890. |
E.C. number | |
Location of functional site(s) | |
Cellular location of function | cilium |
Comments | |
Function 2 |
Function description | regulates NFkappaB signaling |
References for function | McFie M, Koneva L, Collins I, Coveney CR, Clube AM, Chanalaris A, Vincent TL, Bezbradica JS, Sansom SN, Wann AK. Ciliary proteins specify the cell inflammatory response by tuning NFkB signaling, independently of primary cilia. Journal of Cell Science. 2020 Jan 1. PMID: 32503942 |
E.C. number | |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |