Protein Information

General Information
MoonProt ID469
First appeared in release3.0
Name(s)phosphoglucosamine mutase gene: glmM
UniProt IDQ8Y5E6 (GLMM_LISMO)
GO termsGO:0046872 metal ion binding GO:0016853 isomerase activity GO:0008966 phosphoglucosamine mutase activity GO:0000287 magnesium ion binding
Organisms for which functions have been demonstratedListeria monocytogenes (Gram positive bacterium, causes listeriosis, septicemia, meningitis)
Sequence length450 amino acids
FASTA sequence>sp|Q8Y5E6|GLMM_LISMO Phosphoglucosamine mutase OS=Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) OX=169963 GN=glmM PE=3 SV=1 MGKYFGTDGVRGVANSELTPELAFRLGRMGGYVLTRHVGEHPRVLVARDTRISGEMLESALIAGLVSVGIEVMRLGVISTPGVAYLTKAQGASASVMISASHNPVDDNGIKFFGSDGFKLSDDQEEEIEQLLDTAEDTLPRPSGEGLGTVSDYFEGKQKYIQYLKQTIENDFNGYHIALDCANGATSGLATHLFADLDADISSMGASPNGLNINDGVGSTHPEALAAFVLDKKADVGLAFDGDGDRVIAIDEIGQIVDGDKIMFICAKYLREQGLLNNNTIVSTVMSNLGFYKGLKELEIEDVQTAVGDRYVVEAMREGNYNLGGEQSGHIIFLDHNTTGDGLLSGIQLINVMKATGKKLSELAAEMKTFPQKLENIRVSDKNHVTDNPKVSKVIDEVEAEMAGNGRVLVRPSGTEPLVRVMVEAATKEETDEYCERISAVVRSEMALND
Structure Information
PDB IDNA
Quaternary structureNA
SCOP
CATH
TM Helix Predictionno TM helices # sp|Q8Y5E6|GLMM_LISMO Number of predicted TMHs: 0 # sp|Q8Y5E6|GLMM_LISMO Exp number of AAs in TMHs: 0.478909999999999999 # sp|Q8Y5E6|GLMM_LISMO Exp number, first 60 AAs: 0.07193 # sp|Q8Y5E6|GLMM_LISMO Total prob of N-in: 0.02244 sp|Q8Y5E6|GLMM_LISMO TMHMM2.0 outside 1 450
DisProt Annotation
Predicted Disorder RegionsUse FASTA sequence on MFDp2 webserver. spQ8Y5E6GLMM_LISMO_Phosp is 450 residues long, with 0 residues (0.00 %) predicted as disordered. The protein has 0 short (< 30 residues) disorder segments and 0 long (>= 30 residues) disorder segments.
Connections to Disease
OMIM ID
Function 1
Function descriptionphosphoglucosamine mutase. Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
References for functionMengin-Lecreulx D, van Heijenoort J. Characterization of the essential gene glmM encoding phosphoglucosamine mutase in Escherichia coli. J Biol Chem. 1996 Jan 5;271(1):32-9. doi: 10.1074/jbc.271.1.32. PMID: 8550580.
E.C. number5.4.2.10
Location of functional site(s)
Cellular location of function
Comments
Function 2
Function descriptionForms a complex with CdaA and inhibits the diadenylate cyclaseactivity.
References for functionGibhardt J, Heidemann JL, Bremenkamp R, Rosenberg J, Seifert R, Kaever V, Ficner R, Commichau FM. An extracytoplasmic protein and a moonlighting enzyme modulate synthesis of c-di-AMP in Listeria monocytogenes. Environ Microbiol. 2020 Jul;22(7):2771-2791. doi: 10.1111/1462-2920.15008. Epub 2020 Apr 21. PMID: 32250026.
E.C. number
Location of functional site(s)
Cellular location of function
Comments